About: High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody

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About: High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The expression of drebrin, a cytoskeletal protein newly estimated by expression profiling to correlate with the genotype and prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), was examined by independent methods. After demonstrating its higher expression in TEL/AML1(pos) BCP-ALL by quantitative reverse transcriptase polymerase chain reaction, we developed an anti-drebrin monoclonal antibody (mAb). In a cohort of 86 children with BCP-ALL, we found increased expression of drebrin in TEL/AML1(pos) ALL. In conclusion, relationship of drebrin expression and prognosis or genotype can now be assessed using flow cytometry. The expression of drebrin, a cytoskeletal protein newly estimated by expression profiling to correlate with the genotype and prognosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL), was examined by independent methods. After demonstrating its higher expression in TEL/AML1(pos) BCP-ALL by quantitative reverse transcriptase polymerase chain reaction, we developed an anti-drebrin monoclonal antibody (mAb). In a cohort of 86 children with BCP-ALL, we found increased expression of drebrin in TEL/AML1(pos) ALL. In conclusion, relationship of drebrin expression and prognosis or genotype can now be assessed using flow cytometry. (en)
Title	High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody (en)
skos:prefLabel	High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody High expression of cytoskeletal protein drebrin in TEL/AML1(pos) B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody (en)
skos:notation	RIV/68378050:_____/11:00370451!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	I P Z
http://linked.open...avai/riv/aktivity	I, P(2B06064), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Brdička, Tomáš Angelisová, Pavla
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	202014
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00370451
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	drebrin; gene expression profiling; immunophenotyping (en)
http://linked.open.../riv/klicoveSlovo	drebrin gene expression profiling immunophenotyping
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D829A091DC9D]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	New target genes for childhood leukemia diagnosis and treatment focused on adaptor molecules of signaling pathways
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Angelisová, Pavla Brdička, Tomáš Hrušák, O. Kováč, M. Mejstříková, E. Vašková, M. Volná, P. Zuna, J.
http://linked.open...ain/vavai/riv/wos	000292735300024
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0145-2126
number of pages	3 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.leukres.2011.03.028

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