About: Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Novel compounds termed lipophosphonoxins were prepared using a simple and efficient synthetic approach. The general structure of lipophosphonoxins consists of four modules: (i) a nucleoside module, (ii) an iminosugar module, (iii) a hydrophobic module (lipophilic alkyl chain), and (iv) a phosphonate linker module that holds together modules i–iii. Lipophosphonoxins displayed significant antibacterial properties against a panel of Gram-positive species, including multiresistant strains. The minimum inhibitory concentration (MIC) values of the best inhibitors were in the 1–12 .mu.g/mL range, while their cytotoxic concentrations against human cell lines were significantly above this range. The modular nature of this artificial scaffold offers a large number of possibilities for further modifications/exploitation of these compounds. Novel compounds termed lipophosphonoxins were prepared using a simple and efficient synthetic approach. The general structure of lipophosphonoxins consists of four modules: (i) a nucleoside module, (ii) an iminosugar module, (iii) a hydrophobic module (lipophilic alkyl chain), and (iv) a phosphonate linker module that holds together modules i–iii. Lipophosphonoxins displayed significant antibacterial properties against a panel of Gram-positive species, including multiresistant strains. The minimum inhibitory concentration (MIC) values of the best inhibitors were in the 1–12 .mu.g/mL range, while their cytotoxic concentrations against human cell lines were significantly above this range. The modular nature of this artificial scaffold offers a large number of possibilities for further modifications/exploitation of these compounds. (en)
Title	Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties (en)
skos:prefLabel	Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties (en)
skos:notation	RIV/68378050:_____/11:00367626!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	I P V Z
http://linked.open...avai/riv/aktivity	I, P(2B06065), P(GA204/09/0583), P(GAP302/11/0855), P(LC06077), V, Z(AV0Z40550506), Z(AV0Z50200510), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Bartůněk, Petr Pombinho, António R.
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	209660
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00367626
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	lipofosfonoxin; antibacterial; nucleoside (en)
http://linked.open.../riv/klicoveSlovo	lipofosfonoxin nucleoside antibacterial
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5CC7003A6A09]
http://linked.open...i/riv/nazevZdroje	Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	New Generation of Antibacterial Agens RNA polymerase: The “meeting point” of regulatory networks The Delta Subunit of RNA Polymerase from Gram positive Bacteria Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Bartůněk, Petr Krásný, Libor Kolář, M. Nyč, O. Pohl, Radek Zborníková, Eva Šanderová, Hana Bogdanová, K. Kovačková, Soňa Látal, T. Pombinho, António R. Rabatinová, Alžběta Rejman, Dominik
http://linked.open...ain/vavai/riv/wos	000297001600011
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Microorganisms in Research and Biotechnology Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0022-2623
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1021/jm2009343

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