About: Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism

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About: Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Destructive lesions in the heart are a substantial part of Chagas disease pathogenesis. To understand the origin of the heart disease we used a chicken model system in which infection with the pathogen, Trypanosoma cruzi, can be initiated in the egg, but parasite persistence is precluded. In ovo infection generated parasite-free chicks that retained only the mitochondrial kinetoplast DNA minicircle (kDNA) in their genome. Crossbreeding showed that kDNA was transferred vertically to chicken progeny. kDNA integration in coding regions of dystrophin and other genes was shown by cloning the insert together with adjacent chicken sequences. The pathology of kDNA-mutated chickens included heart failure, inflammatory cardiomegaly, and immune attack of heart fibres carried out by CD45(+), CD8γδ(+), and CD8α lymphocytes. We suggest that genetic alterations resulting from kDNA integration lead to autoimmune-mediated destruction of heart tissue in the absence of T. cruzi parasites. Destructive lesions in the heart are a substantial part of Chagas disease pathogenesis. To understand the origin of the heart disease we used a chicken model system in which infection with the pathogen, Trypanosoma cruzi, can be initiated in the egg, but parasite persistence is precluded. In ovo infection generated parasite-free chicks that retained only the mitochondrial kinetoplast DNA minicircle (kDNA) in their genome. Crossbreeding showed that kDNA was transferred vertically to chicken progeny. kDNA integration in coding regions of dystrophin and other genes was shown by cloning the insert together with adjacent chicken sequences. The pathology of kDNA-mutated chickens included heart failure, inflammatory cardiomegaly, and immune attack of heart fibres carried out by CD45(+), CD8γδ(+), and CD8α lymphocytes. We suggest that genetic alterations resulting from kDNA integration lead to autoimmune-mediated destruction of heart tissue in the absence of T. cruzi parasites. (en)
Title	Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism (en)
skos:prefLabel	Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism Trypanosoma cruzi in the chicken model: Chagas-like heart disease in the absence of parasitism (en)
skos:notation	RIV/68378050:_____/11:00365173!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Hejnar, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	236156
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00365173
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chagas disease; Trypanosoma cruzi; kDNA minicircles; inbred chicken (en)
http://linked.open.../riv/klicoveSlovo	Chagas disease Trypanosoma cruzi inbred chicken kDNA minicircles
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A77F0501F01E]
http://linked.open...i/riv/nazevZdroje	PLoS Neglected Tropical Diseases
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Hejnar, Jiří Alvez, R. M. Bernal, F. M. Cordeiro, C. Gomes, C. Guimaro, M. C. Hecht, M. M. Leonardecz, E. Nitz, N. Rosa, A. C. Sousa, A. O. Teixeira, A. R. L.
http://linked.open...ain/vavai/riv/wos	000288940800030
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1935-2735
number of pages	18 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pntd.0001000

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