About: The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure

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About: The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva. Under laboratory conditions, hosts exposed twice to sand fly saliva are protected against severe leishmaniasis. However, people in endemic areas are exposed to the vector over a long term and may experience sand fly-free periods. Therefore, we exposed mice long- or short-term to Phlebotomus duboscqi bites, followed by Leishmania major infection either immediately or after a sand fly-free period. We showed that protection against leishmaniasis is limited to short-term exposure to sand flies immediately before infection. Our results may explain the persistence of leishmaniasis in endemic areas and should be taken into account when designing anti-Leishmania vaccines based on sand fly saliva. (en)
Title	The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure (en)
skos:prefLabel	The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure The protective effect against Leishmania infection conferred by sand fly bites is limited to short-term exposure (en)
skos:notation	RIV/68378050:_____/11:00365117!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA206/09/0777), P(GA206/09/0822), P(LC06009), S, Z(AV0Z50520514), Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lipoldová, Marie Kobets, Tetyana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	224808
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00365117
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Phlebotomus duboscqi; Leishmania major; anti-saliva IgG (en)
http://linked.open.../riv/klicoveSlovo	Leishmania major Phlebotomus duboscqi anti-saliva IgG
http://linked.open...odStatuVydavatele	AU - Australské společenství
http://linked.open...ontrolniKodProRIV	[60AB8E4D03CB]
http://linked.open...i/riv/nazevZdroje	International Journal for Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Vliv hmyzího přenašeče na projevy onemocnění působeného Leishmania infantum Immunological analysis of sand fly - host - Leishmania interactions
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	41
http://linked.open...iv/tvurceVysledku	Volf, P. Lipoldová, Marie Hostomská, J. Kobets, Tetyana Rohoušová, I. Vlková, M.
http://linked.open...ain/vavai/riv/wos	000289402300002
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Ekologické procesy v evoluci modelových skupin organismů
issn	0020-7519
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.ijpara.2011.01.003

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