About: Genetic control of resistance to Trypanosoma brucei brucei infection in mice

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About: Genetic control of resistance to Trypanosoma brucei brucei infection in mice Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal species including livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1–4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes. Trypanosoma brucei are extracellular protozoa transmitted to mammalian host by the tsetse fly. Analysis of genes affecting host's resistance to infection can reveal critical aspects of host-parasite interactions. T. b. brucei infects many animal species including livestock. Mouse strains differ greatly in susceptibility to T. b. brucei. However, genes controlling susceptibility to this parasite have not been mapped. We analyzed the genetic control of survival after T. b. brucei infection using CcS/Dem recombinant congenic strains, each of which contains a different random set of 12.5% genes of their donor parental strain STS/A on the BALB/c genetic background. The RC strain CcS-11 is even more susceptible to parasites than BALB/c or STS/A. In F2 hybrids between BALB/c and CcS-11 we detected and mapped four loci, Tbbr1-4 (Trypanosoma brucei brucei response 1–4), that control survival after T. b. brucei infection. Tbbr2 was precision mapped to a segment of 2.15Mb that contains 26 genes. (en)
Title	Genetic control of resistance to Trypanosoma brucei brucei infection in mice Genetic control of resistance to Trypanosoma brucei brucei infection in mice (en)
skos:prefLabel	Genetic control of resistance to Trypanosoma brucei brucei infection in mice Genetic control of resistance to Trypanosoma brucei brucei infection in mice (en)
skos:notation	RIV/68378050:_____/11:00363620!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(IAA500520606), P(LC06009), V, Z(AV0Z50520514), Z(MSM0021620828)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Vojtíšková, Jarmila Lipoldová, Marie Havelková, Helena Šíma, Matyáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	200985
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00363620
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trypanosoma brucei brucei; mouse recombinant congenic strains; Tbbr (en)
http://linked.open.../riv/klicoveSlovo	Tbbr Trypanosoma brucei brucei mouse recombinant congenic strains
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E31C9EFA2113]
http://linked.open...i/riv/nazevZdroje	PLoS Neglected Tropical Diseases
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Mapping and Identification of Genes that Control Proliferation of Activated Lymphocytes and Study of their Relationship to Disease
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Demant, P. Havelková, Helena Jarošíková, T. Lipoldová, Marie Quan, L. Stassen, A. P. M. Svobodová, M. Vojtíšková, Jarmila Šíma, Matyáš
http://linked.open...ain/vavai/riv/wos	000292139600018
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Ekologické procesy v evoluci modelových skupin organismů
issn	1935-2735
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.pntd.0001173

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