About: STIM1-Directed Reorganization of Microtubules in Activated Mast Cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This research article shows important role of STIM1 protein in activation of bone marrow-derived mast cells. During activation process, mast cells change intracellular level of calcium and present microtubule reorganization. The molecular mechanisms for control microtubule rearrangement during activation events are still unknown. Activation of mast cells results in generation of microtubule protrusions that are calcium dependent. Experiments with knockdown or reexpression of STIM1 protein, the key regulator of store-operated calcium entry, confirmed the important role of STIM1 in the formation of protrusions. This article propose that calcium plays an important role in the formation of microtubule protrusions in mast cells and that rearrangement of microtubules in activated mast cells depends on STIM1-induced calcium entry. This research article shows important role of STIM1 protein in activation of bone marrow-derived mast cells. During activation process, mast cells change intracellular level of calcium and present microtubule reorganization. The molecular mechanisms for control microtubule rearrangement during activation events are still unknown. Activation of mast cells results in generation of microtubule protrusions that are calcium dependent. Experiments with knockdown or reexpression of STIM1 protein, the key regulator of store-operated calcium entry, confirmed the important role of STIM1 in the formation of protrusions. This article propose that calcium plays an important role in the formation of microtubule protrusions in mast cells and that rearrangement of microtubules in activated mast cells depends on STIM1-induced calcium entry. (en)
Title	STIM1-Directed Reorganization of Microtubules in Activated Mast Cells STIM1-Directed Reorganization of Microtubules in Activated Mast Cells (en)
skos:prefLabel	STIM1-Directed Reorganization of Microtubules in Activated Mast Cells STIM1-Directed Reorganization of Microtubules in Activated Mast Cells (en)
skos:notation	RIV/68378050:_____/11:00355825!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/09/1777), P(GA301/09/1826), P(GAP302/10/1759), P(GD204/09/H084), P(KAN200520701), P(LC06063), P(LC545), Z(AV0Z50110509), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Vinopal, Stanislav Dráber, Pavel Dráberová, Eduarda Dráber, Petr Dráberová, Lubica Bugajev, Viktor Hájková, Zuzana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	232399
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00355825
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	STIM1; bonemarrow-derived mast cells; microtubules (en)
http://linked.open.../riv/klicoveSlovo	STIM1 bonemarrow-derived mast cells microtubules
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8E7CEE9EC5B5]
http://linked.open...i/riv/nazevZdroje	Journal of Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Flurescence microscopy in biological and medical research Functional Organisation of the Cell Molecular biology of a differentiating cell Nano-PCR - ultrasensitive test for detection of specific proteins in body fluids Analysis of signaling assemblies containing gamma-tubulin Topography and function of Csk-binding proteins of the plasma membrane in mast cells Function-structure relationships between transmembrane adaptor-based signalosomes in mast cells
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	186
http://linked.open...iv/tvurceVysledku	Hájková, Zuzana Janáček, Jiří Dráber, Pavel Dráberová, Eduarda Vinopal, Stanislav Dráber, Petr Bugajev, Viktor Dráberová, Lubica
http://linked.open...ain/vavai/riv/wos	000285917700030
http://linked.open...n/vavai/riv/zamer	Výzkum molekulárních a buněčných základů fyziologických a patofyziologických procesů s cílem objasnit mechanismy vzniku závažných onemocnění člověka Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0022-1767
number of pages	11 (xsd:int)

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