About: Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model

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About: Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A new model of orthotopic limbal transplantation was established in the mouse. The survival of limbal autografts, allografts and xenografts was characterized according to the clinical criteria, and intragraft cytokine response was determined by a real-time PCR. The results showed that the limbal grafts do not enjoy immune privilege of the eye and are promptly rejected by Th1 or combined Th1 and Th2 type of immune response involving CD4 pozitive cells and iNOS expression. Targeting this pathway may be an effective way to prevent and treat limbal graft rejection. A new model of orthotopic limbal transplantation was established in the mouse. The survival of limbal autografts, allografts and xenografts was characterized according to the clinical criteria, and intragraft cytokine response was determined by a real-time PCR. The results showed that the limbal grafts do not enjoy immune privilege of the eye and are promptly rejected by Th1 or combined Th1 and Th2 type of immune response involving CD4 pozitive cells and iNOS expression. Targeting this pathway may be an effective way to prevent and treat limbal graft rejection. (en)
Title	Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model (en)
skos:prefLabel	Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model Graft survival and cytokine production profile after limbal transplantation in the experimental mouse model (en)
skos:notation	RIV/68378050:_____/11:00355310!RIV12-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(GD310/08/H077), P(KAN200520804), Z(AV0Z50520514), Z(MSM0021620806), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lenčová, Anna Holáň, Vladimír Pokorná, Kateřina Zajícová, Alena Krulová, Magdalena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	201482
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/11:00355310
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	limbal transplantation; graft survival; cytokine response (en)
http://linked.open.../riv/klicoveSlovo	cytokine response limbal transplantation graft survival
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[531BBFC0A7DD]
http://linked.open...i/riv/nazevZdroje	Transplant Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances Center of Molecular and Cellular Immunology Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Holáň, Vladimír Krulová, Magdalena Zajícová, Alena Filipec, M. Lenčová, Anna Pokorná, Kateřina
http://linked.open...ain/vavai/riv/wos	000288478500008
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Molekulární biologie a patologie buňky za normy a u vybraných klinicky závažných patologických procesů Signaling and cellular response mechanisms
issn	0966-3274
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.trim.2010.11.005

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