About: Cytokines shape chemotherapy-induced and 'bystander' senescence

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Cytokines shape chemotherapy-induced and 'bystander' senescence Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In this short summary we discuss our recently published data about the newly emerging role of autocrine and paracrine cytokine signaling pathways in development of senescent phenotype in perspective of other data reported. DNA damage response activated by chronic subtoxic stresses leads to expression of cytokine encoding genes either primarily due to DNA damage activated kinases and/or secondarily through autocrine and paracrine effects of secreted cytokines, which activate network of cytokine-driven signaling pathways such as JAK/STAT. Changed gene expression pattern of senescent cells includes several tumor suppressors such as interferons, PML, STAT and IRF1. Intriguingly, persistent exposition of cells to conditioned media of chemotherapy-induced senescent cells is able to evoke premature senescence in neighbouring 'bystanding' cells. In this short summary we discuss our recently published data about the newly emerging role of autocrine and paracrine cytokine signaling pathways in development of senescent phenotype in perspective of other data reported. DNA damage response activated by chronic subtoxic stresses leads to expression of cytokine encoding genes either primarily due to DNA damage activated kinases and/or secondarily through autocrine and paracrine effects of secreted cytokines, which activate network of cytokine-driven signaling pathways such as JAK/STAT. Changed gene expression pattern of senescent cells includes several tumor suppressors such as interferons, PML, STAT and IRF1. Intriguingly, persistent exposition of cells to conditioned media of chemotherapy-induced senescent cells is able to evoke premature senescence in neighbouring 'bystanding' cells. (en)
Title	Cytokines shape chemotherapy-induced and 'bystander' senescence Cytokines shape chemotherapy-induced and 'bystander' senescence (en)
skos:prefLabel	Cytokines shape chemotherapy-induced and 'bystander' senescence Cytokines shape chemotherapy-induced and 'bystander' senescence (en)
skos:notation	RIV/68378050:_____/10:00353769!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/08/1418), P(GA301/08/0353), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Bártek, Jiří Hodný, Zdeněk Hubáčková, Soňa
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	252650
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00353769
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bystander cellular senescence; cytokines; PML (en)
http://linked.open.../riv/klicoveSlovo	cytokines PML bystander cellular senescence
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[81A8AECA076B]
http://linked.open...i/riv/nazevZdroje	Aging
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of the JAK/STAT signalling pathway in cellular senescence Protein modifications in DNA damage signalling: Mechanisms and cancer relevance
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Hodný, Zdeněk Bartek, Jiří Hubáčková, Soňa
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1945-4589
number of pages	2 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software