About: Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts

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About: Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In mast cells and basophils activated by multivalent antigen-IgE complexes, tyrosine phosphorylation of the high affinity IgE receptor (FcepsilonRI) is mediated by Src family protein tyrosine (PTK) kinase Lyn. However, the exact molecular mechanism of this phosphorylation step is incompletely understood. In this study, we tested the hypothesis that changes in activity and/or topography of protein-tyrosine phosphatases (PTPs) could play a major role in the FcepsilonRI triggering. We found that exposure of rat basophilic leukemia cells or mouse bone marrow-derived mast cells to PTP inhibitors, H2O2 or pervanadate, induced phosphorylation of the FcepsilonRI subunits, similarly as FcepsilonRI triggering. Interestingly, and in sharp contrast to antigen-induced activation, neither H2O2 nor pervanadate induced any changes in the association of FcepsilonRI with detergent-resistant membranes on isolated plasma membrane sheets. In mast cells and basophils activated by multivalent antigen-IgE complexes, tyrosine phosphorylation of the high affinity IgE receptor (FcepsilonRI) is mediated by Src family protein tyrosine (PTK) kinase Lyn. However, the exact molecular mechanism of this phosphorylation step is incompletely understood. In this study, we tested the hypothesis that changes in activity and/or topography of protein-tyrosine phosphatases (PTPs) could play a major role in the FcepsilonRI triggering. We found that exposure of rat basophilic leukemia cells or mouse bone marrow-derived mast cells to PTP inhibitors, H2O2 or pervanadate, induced phosphorylation of the FcepsilonRI subunits, similarly as FcepsilonRI triggering. Interestingly, and in sharp contrast to antigen-induced activation, neither H2O2 nor pervanadate induced any changes in the association of FcepsilonRI with detergent-resistant membranes on isolated plasma membrane sheets. (en)
Title	Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts (en)
skos:prefLabel	Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts Down-regulation of protein-tyrosine phosphatases activates an immune receptor in the absence of its translocation into lipid rafts (en)
skos:notation	RIV/68378050:_____/10:00346787!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0505), P(1M0506), P(GA301/09/1826), P(GAP302/10/1759), P(KAN200520701), P(LC545), Z(AV0Z50200510), Z(AV0Z50520514), Z(MSM0021620814)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Heneberg, Petr Bambousková, Monika Dráber, Petr Dráberová, Lubica
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	255195
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00346787
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mast cell; cell signaling; plasma membrane (en)
http://linked.open.../riv/klicoveSlovo	plasma membrane cell signaling mast cell
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E04FC0376F2C]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of targeted therapeutic drugs Functional Organisation of the Cell Center of Molecular and Cellular Immunology Nano-PCR - ultrasensitive test for detection of specific proteins in body fluids Topography and function of Csk-binding proteins of the plasma membrane in mast cells Function-structure relationships between transmembrane adaptor-based signalosomes in mast cells
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	285
http://linked.open...iv/tvurceVysledku	Heneberg, Petr Pompach, Petr Bambousková, Monika Dráber, Petr Dráberová, Lubica
http://linked.open...ain/vavai/riv/wos	000276787800037
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Prevention, diagnostics and therapy of diabetes mellitus, metabolic and endocrine damage of organism
issn	0021-9258
number of pages	16 (xsd:int)

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