About: Immunoregulatory properties of mouse limbal stem cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We isolated a highly purified population of mouse limbal stem cells. These cells expressed immunosuppressive and immunoregulatory properties. In addition, limbal stem cells had a high expression of genes for the anti-apoptotic molecules Bcl-1, XIAP and Survivin and for Fas ligand, and displayed an enhanced resistence to the apoptosis-inducing agents and to cell-mediated immunity. The results thus showed novel undescribed properties of adult stem cells. These immunoregulatory and self-protecting properties of adult tissue specific stem cells can be responsible for protection of stem cells which have a vital role in reparation and regeneration of tissues and organs. We isolated a highly purified population of mouse limbal stem cells. These cells expressed immunosuppressive and immunoregulatory properties. In addition, limbal stem cells had a high expression of genes for the anti-apoptotic molecules Bcl-1, XIAP and Survivin and for Fas ligand, and displayed an enhanced resistence to the apoptosis-inducing agents and to cell-mediated immunity. The results thus showed novel undescribed properties of adult stem cells. These immunoregulatory and self-protecting properties of adult tissue specific stem cells can be responsible for protection of stem cells which have a vital role in reparation and regeneration of tissues and organs. (en)
Title	Immunoregulatory properties of mouse limbal stem cells Immunoregulatory properties of mouse limbal stem cells (en)
skos:prefLabel	Immunoregulatory properties of mouse limbal stem cells Immunoregulatory properties of mouse limbal stem cells (en)
skos:notation	RIV/68378050:_____/10:00346785!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0506), P(GD310/08/H077), P(KAN200520804), Z(AV0Z50520514), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Holáň, Vladimír Pokorná, Kateřina Zajícová, Alena Procházková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	262917
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00346785
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Limbal stem cells; immunoregulation; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	immunoregulation apoptosis Limbal stem cells
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[9586F8D4509C]
http://linked.open...i/riv/nazevZdroje	Journal of Immunology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biocompatible nanofiber scaffolds forming novel drug matrices for the application of biologically and pharmacologically active substances Center of Molecular and Cellular Immunology Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	184
http://linked.open...iv/tvurceVysledku	Procházková, Jana Holáň, Vladimír Zajícová, Alena Pokorná, Kateřina Krulová, M.
http://linked.open...ain/vavai/riv/wos	000274585100047
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Signaling and cellular response mechanisms
issn	0022-1767
number of pages	6 (xsd:int)

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