About: Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas

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About: Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Retroviruses and retrovirus-derived vectors integrate non-randomly into the genomes of host cells with specific preferences for transcribed genes, gene-rich regions, and CpG islands. To understand the genomic features that influence transcriptinal activity of integrated retroviruses, we cloned and analyzed the integration sites of avian sarcoma virus from chicken tumors. Growing progressively in dependence on high and stable expression of the transduced v-src oncogene, these tumors represent clonal expansions of cells bearing transcriptionally active replication-defective proviruses. Our analysis showed striking accumulation within or close to transcription units, particularly in genes broadly expressed in multiple tissues but not in tissue-specifically expressed genes. We infer that proviruses integrated in these genomic areas efficiently avoid transcriptional silencing and keep active for a long time during the growth of tumors. Retroviruses and retrovirus-derived vectors integrate non-randomly into the genomes of host cells with specific preferences for transcribed genes, gene-rich regions, and CpG islands. To understand the genomic features that influence transcriptinal activity of integrated retroviruses, we cloned and analyzed the integration sites of avian sarcoma virus from chicken tumors. Growing progressively in dependence on high and stable expression of the transduced v-src oncogene, these tumors represent clonal expansions of cells bearing transcriptionally active replication-defective proviruses. Our analysis showed striking accumulation within or close to transcription units, particularly in genes broadly expressed in multiple tissues but not in tissue-specifically expressed genes. We infer that proviruses integrated in these genomic areas efficiently avoid transcriptional silencing and keep active for a long time during the growth of tumors. (en)
Title	Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas (en)
skos:prefLabel	Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas (en)
skos:notation	RIV/68378050:_____/10:00346752!RIV11-GA0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/07/1030), P(GP301/09/P667), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kotáb, Jan Hejnar, Jiří Plachý, Jiří Divina, Petr Reinišová, Markéta Šenigl, Filip
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	283180
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00346752
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	avian sarcoma virus; retrovirus integration; position effects (en)
http://linked.open.../riv/klicoveSlovo	retrovirus integration avian sarcoma virus position effects
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5E7AE44ED3FA]
http://linked.open...i/riv/nazevZdroje	Journal of Virology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Transcriptional silencing of retroviral vectors during their integration into the host genome Integration preference of retroviruses
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	84
http://linked.open...iv/tvurceVysledku	Plachý, Jiří Hejnar, Jiří Divina, Petr Reinišová, Markéta Šenigl, Filip Kotáb, Jan
http://linked.open...ain/vavai/riv/wos	000276358000009
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0022-538X
number of pages	8 (xsd:int)

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