About: Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility

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About: Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth. Previously we mapped four loci (Lynf1-Lynf4) controlling lymphocyte infiltration of mouse lung tumors. These loci do not encode any of the molecules that are involved in traffic of lymphocytes. Here we report a genetic relationship between these loci and the control of production of IFNgamma in allogeneic mixed lymphocyte cultures (MLC). We found that IFNgamma production by lymphocytes of O20/A mice is lower than by OcB-9/Dem (both H2 ( pz )) stimulated in MLC by irradiated splenocytes of C57BL/10SnPh (H2 ( b )) or BALB/cHeA (H2 ( d )) mice, or by ConA. IFNgamma production in MLCs of F2 (O20 x OcB-9) mice stimulated by irradiated C57BL/10 MLC revealed four IFNgamma-controlling loci (Cypr4-Cypr7), each of which is closely linked with one of the four Lynf loci and with a cluster of susceptibility genes for different tumors. This suggests that inherited differences in certain lymphocyte responses may modify their propensity to infiltrate tumors and their capacity to affect tumor growth. (en)
Title	Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility (en)
skos:prefLabel	Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility (en)
skos:notation	RIV/68378050:_____/10:00334121!RIV10-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GD310/08/H077), P(IAA500520606), P(LC06009), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vojtíšková, Jarmila Lipoldová, Marie Havelková, Helena Krulová, Magdalena Badalová, Jana Sohrabi, Yahya
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	268776
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/10:00334121
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Tumor susceptibility; Genetic control of interferon gamma production; Lymphocyte infiltration of tumors (en)
http://linked.open.../riv/klicoveSlovo	Genetic control of interferon gamma production Lymphocyte infiltration of tumors Tumor susceptibility
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[514FCA4AB3BD]
http://linked.open...i/riv/nazevZdroje	Cancer Immunology and Immunotherapy
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Mapping and Identification of Genes that Control Proliferation of Activated Lymphocytes and Study of their Relationship to Disease Regulation of immunological mechanisms in health and disease:Development of new diagnostic and therapeutic approaches
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	59
http://linked.open...iv/tvurceVysledku	Krulová, Magdalena Demant, P. Havelková, Helena Lipoldová, Marie Quan, L. Stassen, A. P. M. Vojtíšková, Jarmila Sohrabi, Yahya Badalová, Jana
http://linked.open...ain/vavai/riv/wos	000271748600003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0340-7004
number of pages	11 (xsd:int)

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