About: Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells

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About: Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Migration plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the collaboration of Akt, FAK and Src kinases in migration and invasion of colorectal cancer cells. We show that all three kinases can be found in one protein complex but the interaction between Akt and Src is indirect and mediated by FAK. Interestingly, induced Akt signaling causes an increased tyrosine phosphorylation of FAK but this increase is attenuated by Src inhibitor SU6656. We also show that active Akt stimulates cell migration, but this phenomenon is blocked by FAK knockdown or by inhibition of Src kinase. In addition, all three kinases appeared crucial for successful invasion of colorectal cancer cells. Alltogether, our data suggest the mechanism how the pathway can affect migration of colorectal adenocarcinoma cells. Since FAK acts downstream of Akt, our results imply FAK kinase as a potential key molecule during progression of tumors with active PI3-K/Akt signaling. Migration plays a crucial role in cancer cell invasion and metastasis. The focus of this study is the collaboration of Akt, FAK and Src kinases in migration and invasion of colorectal cancer cells. We show that all three kinases can be found in one protein complex but the interaction between Akt and Src is indirect and mediated by FAK. Interestingly, induced Akt signaling causes an increased tyrosine phosphorylation of FAK but this increase is attenuated by Src inhibitor SU6656. We also show that active Akt stimulates cell migration, but this phenomenon is blocked by FAK knockdown or by inhibition of Src kinase. In addition, all three kinases appeared crucial for successful invasion of colorectal cancer cells. Alltogether, our data suggest the mechanism how the pathway can affect migration of colorectal adenocarcinoma cells. Since FAK acts downstream of Akt, our results imply FAK kinase as a potential key molecule during progression of tumors with active PI3-K/Akt signaling. (en)
Title	Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells (en)
skos:prefLabel	Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells Focal Adhesion Kinase functions as an Akt downstream target in migration of colorectal cancer cells (en)
skos:notation	RIV/68378050:_____/09:00335669!RIV10-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06077), P(GA204/06/1658), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vojtěchová, Martina Kořínek, Vladimír Krausová, Michaela Šloncová, Eva Turečková, Jolana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	315312
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00335669
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	FAK; migration; invasion (en)
http://linked.open.../riv/klicoveSlovo	migration invasion FAK
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[E6BEB2E332DE]
http://linked.open...i/riv/nazevZdroje	Translational Oncology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	High throughput analysis of chromatin structure for development of novel diagnostic and therapeutic approaches in cancer. Putative role of Akt and PKC beta II in FAK-dependent migration or invasion of colorectal cancer cells
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Kořínek, Vladimír Krausová, Michaela Turečková, Jolana Vojtěchová, Martina Šloncová, Eva
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1936-5233
number of pages	10 (xsd:int)

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