About: Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia

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About: Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog, house dust mites), total IgE overproduction and airway hyperreactivity. Definition of genes predisposing to development of various subcomponents of asthma phenotype is important for understanding etiology of this disease. We tested 21 microsatellite markers from candidate chromosomal regions in 136 Russian nuclear families with asthma from Siberia. The most significant linkage was to the candidate region on chromosome 12. Locus controlling cat-specific IgE was mapped within the interval 136-140 cM on chromosome 12q24.3. Total IgE was also linked to this region. FEV1 (%) exceeded LOD> 1 threshold for significance with the same locus but more proximally. Some evidence of linkage was also detected for asthma at 6p21.31 and total IgE at 13q14.2. Locus 12q24.3 thus seems the most promising candidate for identification of asthma genes in Russian population of Siberia. In Russian population of Siberia asthma is usually concomitant with high sensitization to indoor allergens (cat, dog, house dust mites), total IgE overproduction and airway hyperreactivity. Definition of genes predisposing to development of various subcomponents of asthma phenotype is important for understanding etiology of this disease. We tested 21 microsatellite markers from candidate chromosomal regions in 136 Russian nuclear families with asthma from Siberia. The most significant linkage was to the candidate region on chromosome 12. Locus controlling cat-specific IgE was mapped within the interval 136-140 cM on chromosome 12q24.3. Total IgE was also linked to this region. FEV1 (%) exceeded LOD> 1 threshold for significance with the same locus but more proximally. Some evidence of linkage was also detected for asthma at 6p21.31 and total IgE at 13q14.2. Locus 12q24.3 thus seems the most promising candidate for identification of asthma genes in Russian population of Siberia. (en)
Title	Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia (en)
skos:prefLabel	Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia (en)
skos:notation	RIV/68378050:_____/09:00334127!RIV10-MSM-68378050
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA310/06/1745), P(LC06009), S, Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Gusareva, Elena Lipoldová, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	307048
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00334127
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IgE; asthma; cat allergens (en)
http://linked.open.../riv/klicoveSlovo	IgE asthma cat allergens
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B752D60AA37B]
http://linked.open...i/riv/nazevZdroje	Immunology Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Fine mapping and molecular identification of genes that control response to Leishmania major
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	125
http://linked.open...iv/tvurceVysledku	Lipoldová, Marie Gusareva, Elena Bragina, E. J. Buinova, S. N. Chernyak, B. A. Ogorodova, L. M. Puzyrev, V. P.
http://linked.open...ain/vavai/riv/wos	000268649300001
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0165-2478
number of pages	6 (xsd:int)

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