About: Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection

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About: Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Leishmania major infection in mice is an important model of host-pathogen relationship. Infected BALB/c mice exhibit high parasite numbers in lymph nodes and spleens and chronic disease with skin lesions, splenomegaly, hepatomegaly, increased serum IgE levels and cytokine imbalance. Linkage analysis integrated with study of multiple manifestations of infection in (BALB/c x CcS-11) F2 hybrids mapped 5 loci, 2 of which control parasite elimination or dissemination. Lmr5 influences parasite loads in spleens (+ skin lesions, splenomegaly, serum IgE, IL-4, and IFNg levels) and Lmr20 determines parasite numbers in draining lymph nodes (+ serum IgE and IFNg levels) but no skin or visceral pathology. Three additional loci do not affect parasite numbers but significantly influence disease phenotype - Lmr21: skin lesions, IFNg levels, Lmr22: IL-4 levels, Lmr23: IFNg levels, indicating that L. major-caused disease development includes critical regulations additional to control of parasite spread. Leishmania major infection in mice is an important model of host-pathogen relationship. Infected BALB/c mice exhibit high parasite numbers in lymph nodes and spleens and chronic disease with skin lesions, splenomegaly, hepatomegaly, increased serum IgE levels and cytokine imbalance. Linkage analysis integrated with study of multiple manifestations of infection in (BALB/c x CcS-11) F2 hybrids mapped 5 loci, 2 of which control parasite elimination or dissemination. Lmr5 influences parasite loads in spleens (+ skin lesions, splenomegaly, serum IgE, IL-4, and IFNg levels) and Lmr20 determines parasite numbers in draining lymph nodes (+ serum IgE and IFNg levels) but no skin or visceral pathology. Three additional loci do not affect parasite numbers but significantly influence disease phenotype - Lmr21: skin lesions, IFNg levels, Lmr22: IL-4 levels, Lmr23: IFNg levels, indicating that L. major-caused disease development includes critical regulations additional to control of parasite spread. (en)
Title	Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection (en)
skos:prefLabel	Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection (en)
skos:notation	RIV/68378050:_____/09:00334105!RIV10-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA310/06/1745), P(LC06009), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kurey, Irina Trtková, Kateřina Lipoldová, Marie Havelková, Helena Grekov, Igor Kobets, Tetyana Slapničková, Martina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	310817
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00334105
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Leishmania major; Parasite elimination; QTL mapping (en)
http://linked.open.../riv/klicoveSlovo	QTL mapping Leishmania major Parasite elimination
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[C551DC961370]
http://linked.open...i/riv/nazevZdroje	Immunogenetics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	7 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Fine mapping and molecular identification of genes that control response to Leishmania major
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	61
http://linked.open...iv/tvurceVysledku	Demant, P. Havelková, Helena Lipoldová, Marie Quan, L. Stassen, A. P. M. Svobodová, M. Trtková, Kateřina Grekov, Igor Kobets, Tetyana Kurey, Irina Slapničková, Martina Hutson, A.
http://linked.open...ain/vavai/riv/wos	000269853400003
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0093-7711
number of pages	15 (xsd:int)

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