About: Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium

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About: Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Wnt/beta-catenin signaling is highly active in the dorsal retinal pigment epithelium (RPE) during eye development. To study the role of Wnt/beta-catenin signaling in the RPE development we used a conditional Cre/loxP system in mice to inactivate or ectopically activate Wnt/beta-catenin signaling in the RPE. Inactivation of Wnt/beta-catenin signaling results in transdifferentiation of RPE to neural retina (NR) as documented by downregulation of RPE-specific markers Mitf and Otx2 and ectopic expression of NR-specific markers Chx10 and Rx, respectively. In contrast, ectopic activation of Wnt/beta-catenin signaling results in the disruption of the RPE patterning, indicating that precise spatial and temporal regulation of Wnt/beta-catenin signaling is required for normal RPE development. Combined, our data suggest that Wnt/beta-catenin signaling plays an essential role in development of RPE by maintaining or inducing expression of Mitf and Otx2. Wnt/beta-catenin signaling is highly active in the dorsal retinal pigment epithelium (RPE) during eye development. To study the role of Wnt/beta-catenin signaling in the RPE development we used a conditional Cre/loxP system in mice to inactivate or ectopically activate Wnt/beta-catenin signaling in the RPE. Inactivation of Wnt/beta-catenin signaling results in transdifferentiation of RPE to neural retina (NR) as documented by downregulation of RPE-specific markers Mitf and Otx2 and ectopic expression of NR-specific markers Chx10 and Rx, respectively. In contrast, ectopic activation of Wnt/beta-catenin signaling results in the disruption of the RPE patterning, indicating that precise spatial and temporal regulation of Wnt/beta-catenin signaling is required for normal RPE development. Combined, our data suggest that Wnt/beta-catenin signaling plays an essential role in development of RPE by maintaining or inducing expression of Mitf and Otx2. (en)
Title	Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium (en)
skos:prefLabel	Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium (en)
skos:notation	RIV/68378050:_____/09:00334091!RIV10-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(2B06077), P(GA204/08/1618), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kozmik, Zbyněk Kořínek, Vladimír Fujimura, Naoko
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	342726
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00334091
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	eye; Wnt; retina; pigment (en)
http://linked.open.../riv/klicoveSlovo	retina eye pigment Wnt
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[51A9BF326BAA]
http://linked.open...i/riv/nazevZdroje	Developmental Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	High throughput analysis of chromatin structure for development of novel diagnostic and therapeutic approaches in cancer. Molecular basis of canonical Wnt signalling during eye and brain development Center for Applied Genomics
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	334
http://linked.open...iv/tvurceVysledku	Kozmik, Zbyněk Kořínek, Vladimír Fujimura, Naoko Mori, M. Taketo, M. M.
http://linked.open...ain/vavai/riv/wos	000272260600004
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0012-1606
number of pages	15 (xsd:int)

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