About: CpG methylation controls reactivation of HIV from latency

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	HIV-1 latency is the main obstacle to the eradication of the virus from infected patients. CpG methylation is known to contribute to transcriptional silencing in general, its role in HIV-1 latency, however, has not been clearly demonstrated and has never been studied in HIV-1-infected patients. We found in an in vitro model and in HIV-1-infected patients that CpG methylation of the HIV-1 promoter is important for the maintenance but not for the establishment of HIV-1 latency. That tight control of HIV-1 latency by CpG methylation could be a key barrier to purging the reservoir of latently infected cells in infected individuals. Our study shows that addition of some histone deacetylase and methyltransferase inhibitors (namely SAHA) reactivate latent HIV and could represent an important part of HAART protocols in the future. HIV-1 latency is the main obstacle to the eradication of the virus from infected patients. CpG methylation is known to contribute to transcriptional silencing in general, its role in HIV-1 latency, however, has not been clearly demonstrated and has never been studied in HIV-1-infected patients. We found in an in vitro model and in HIV-1-infected patients that CpG methylation of the HIV-1 promoter is important for the maintenance but not for the establishment of HIV-1 latency. That tight control of HIV-1 latency by CpG methylation could be a key barrier to purging the reservoir of latently infected cells in infected individuals. Our study shows that addition of some histone deacetylase and methyltransferase inhibitors (namely SAHA) reactivate latent HIV and could represent an important part of HAART protocols in the future. (en)
Title	CpG methylation controls reactivation of HIV from latency CpG methylation controls reactivation of HIV from latency (en)
skos:prefLabel	CpG methylation controls reactivation of HIV from latency CpG methylation controls reactivation of HIV from latency (en)
skos:notation	RIV/68378050:_____/09:00333948!RIV10-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/05/0939), P(GP204/08/P616), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Blažková, Jana Hejnar, Jiří Trejbalová, Kateřina
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	308475
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00333948
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV-1; proviral latency; CpG methylation; histone modifications; HAART; epigenetics (en)
http://linked.open.../riv/klicoveSlovo	CpG methylation proviral latency epigenetics histone modifications HIV-1 HAART
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6062897B0CFC]
http://linked.open...i/riv/nazevZdroje	Plos Pathogenes
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	CpG methylation of human endogenous retroviruses and LINEs The role of DNA methylation and histone modifications in the establishment and maintenance of HIV-1 latency
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Blažková, Jana Hejnar, Jiří Hirsch, I. Trejbalová, Kateřina Gondois-Rey, F. Guiguen, A. Halfon, P. Olive, D. Philibert, P. Van Lint, C. Verdin, E.
http://linked.open...ain/vavai/riv/wos	000270804500010
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1553-7374
number of pages	14 (xsd:int)

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