About: Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination

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About: Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We describe models of preventive and therapeutic vaccination of sarcoma-bearing rats with dendritic cells (DC) presenting tumour antigens from killed tumour cells, together with characteristics of DC-based vaccine and its capacity to induce anti-tumour immune response both in vitro and in vivo. We show that preventive vaccination efficiently prevents tumour growth. However, vaccination of rats with established tumours did not lead to eradication of the tumours – despite induction of a vigorous immune response and transient decrease in tumour progression, tumours eventually resumed growth. Preventive and therapeutic DC-based vaccination induced strong tumour-specific T-cell response. These results argue for the timing of cancer immunotherapy to the stages of low tumour load. Immunotherapy at the stage of minimal residual disease, after reduction of tumour load by other modalities, should offer a better clinical benefit to cancer patients than immunotherapy of metastatic disease. We describe models of preventive and therapeutic vaccination of sarcoma-bearing rats with dendritic cells (DC) presenting tumour antigens from killed tumour cells, together with characteristics of DC-based vaccine and its capacity to induce anti-tumour immune response both in vitro and in vivo. We show that preventive vaccination efficiently prevents tumour growth. However, vaccination of rats with established tumours did not lead to eradication of the tumours – despite induction of a vigorous immune response and transient decrease in tumour progression, tumours eventually resumed growth. Preventive and therapeutic DC-based vaccination induced strong tumour-specific T-cell response. These results argue for the timing of cancer immunotherapy to the stages of low tumour load. Immunotherapy at the stage of minimal residual disease, after reduction of tumour load by other modalities, should offer a better clinical benefit to cancer patients than immunotherapy of metastatic disease. (en)
Title	Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination (en)
skos:prefLabel	Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination Dendritic cell-based immunotherapy induces transient clinical response in advanced rat fibrosarcoma - comparison with preventive anti-tumour vaccination (en)
skos:notation	RIV/68378050:_____/09:00333752!RIV10-AV0-68378050
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50520514), Z(MSM0021620812)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Pajer, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	309440
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00333752
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	dendritic cells; immunotherapy; cancer immunotherapy; chemotherapy (en)
http://linked.open.../riv/klicoveSlovo	immunotherapy dendritic cells chemotherapy cancer immunotherapy
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[E3D5974BADC2]
http://linked.open...i/riv/nazevZdroje	Folia Biologica
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	55
http://linked.open...iv/tvurceVysledku	Pýcha, K. Pajer, Petr Špíšek, R. Kučera, A. Škába, R.
http://linked.open...ain/vavai/riv/wos	000269369200001
http://linked.open...n/vavai/riv/zamer	Chronická onemocnění vznikající na podkladě nepřiměřené reaktivity imunitního systému, jejich patogeneze a možnosti včasné diagnostiky a léčby Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0015-5500
number of pages	7 (xsd:int)

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