About: Industasis, a promotion of tumor formation by nontumorigenic stray cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have demonstrated that transient presence of non-tumorigenic stray cells in tissues of experimental animals containing cells with a sub-critical set of genetic mutations can act as a tumor-promoting stimulus. To induce somatic mutations in all chicken tissues we used MAV-2 retroviral insertion system almost exclusively generating nephroblastomas. MAV-2 mutagenized animals inoculated with non-malignant cells developed early clonal lung tumors prior to nephroblastomas. Importantly, injected cells did not become a component of resultant tumors. Lung tumors displayed specific mutational signature characterized by insertion of MAV-2 provirus into frk promoter resulting in over-expression of gene frk. In contrast, plag1, foxP1 and twist genes were most often mutagenized in nephroblastomas. We propose the mechanism termed industasis, a promotion of fully malignant phenotype of incipient tumor cell by stray cells, and hypothesize that it might be a cause of human multiple primary tumors. We have demonstrated that transient presence of non-tumorigenic stray cells in tissues of experimental animals containing cells with a sub-critical set of genetic mutations can act as a tumor-promoting stimulus. To induce somatic mutations in all chicken tissues we used MAV-2 retroviral insertion system almost exclusively generating nephroblastomas. MAV-2 mutagenized animals inoculated with non-malignant cells developed early clonal lung tumors prior to nephroblastomas. Importantly, injected cells did not become a component of resultant tumors. Lung tumors displayed specific mutational signature characterized by insertion of MAV-2 provirus into frk promoter resulting in over-expression of gene frk. In contrast, plag1, foxP1 and twist genes were most often mutagenized in nephroblastomas. We propose the mechanism termed industasis, a promotion of fully malignant phenotype of incipient tumor cell by stray cells, and hypothesize that it might be a cause of human multiple primary tumors. (en)
Title	Industasis, a promotion of tumor formation by nontumorigenic stray cells Industasis, a promotion of tumor formation by nontumorigenic stray cells (en)
skos:prefLabel	Industasis, a promotion of tumor formation by nontumorigenic stray cells Industasis, a promotion of tumor formation by nontumorigenic stray cells (en)
skos:notation	RIV/68378050:_____/09:00333751!RIV10-MSM-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/06/1728), P(IAA500520608), P(LC06061), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Průková, Dana Dvořák, Michal Pečenka, Vladimír Karafiát, Vít Plachý, Jiří Pajer, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	319084
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00333751
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tumor promotion; lung tumors; Fyn-related kinase (en)
http://linked.open.../riv/klicoveSlovo	tumor promotion lung tumors Fyn-related kinase
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8A6F17A9E0C8]
http://linked.open...i/riv/nazevZdroje	Cancer Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of Cell Invasiveness in Embryonic Development and Tumour Metastases Bone marrow microenvironment in the development of monoblastic leukaemia Protein transduction as a tool to study a function of Myb proteins
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	69
http://linked.open...iv/tvurceVysledku	Dvořák, Michal Karafiát, Vít Pečenka, Vladimír Plachý, Jiří Pajer, Petr Průková, Dana Dudlová, J. Kašparová, P.
http://linked.open...ain/vavai/riv/wos	000266755000010
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0008-5472
number of pages	8 (xsd:int)

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