About: A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The global HIV/AIDS epidemic consists of a number of regional epidemics caused by different HIV-1 subtypes prevailing in different regions. We have studied changes in genetic diversity of HIV-1 strains isolated in the Czech Republic (CR) over a more than twenty-year period (1986–2007). HIV-1 strains isolated in CR from 1986 to 2007 were subtyped by pol gene sequencing followed by phylogenetic analysis. A wide range of HIV-1 subtypes were found, with subtype B, into which 76.6 % of 534 HIV-1 isolates were classified, being predominant during the whole study period. An increasing number of non-B subtypes A1, C, D, F1, G and some recombinant forms (CRF 01_AE, CRF 02_AG and CRF 06_cpx) were identified after 1990. The absolute predominance of subtype B among HIV-1 strains in CR ended in 1991 when different non-B subtypes had been introduced into the country. The East-West migration is responsible for the introduction of HIV-1 subtypes prevalent in Eastern European and some Asian countries. The global HIV/AIDS epidemic consists of a number of regional epidemics caused by different HIV-1 subtypes prevailing in different regions. We have studied changes in genetic diversity of HIV-1 strains isolated in the Czech Republic (CR) over a more than twenty-year period (1986–2007). HIV-1 strains isolated in CR from 1986 to 2007 were subtyped by pol gene sequencing followed by phylogenetic analysis. A wide range of HIV-1 subtypes were found, with subtype B, into which 76.6 % of 534 HIV-1 isolates were classified, being predominant during the whole study period. An increasing number of non-B subtypes A1, C, D, F1, G and some recombinant forms (CRF 01_AE, CRF 02_AG and CRF 06_cpx) were identified after 1990. The absolute predominance of subtype B among HIV-1 strains in CR ended in 1991 when different non-B subtypes had been introduced into the country. The East-West migration is responsible for the introduction of HIV-1 subtypes prevalent in Eastern European and some Asian countries. (en)
Title	A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007 A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007 (en)
skos:prefLabel	A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007 A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007 (en)
skos:notation	RIV/68378050:_____/09:00333601!RIV10-AV0-68378050
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR7843), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Reiniš, Milan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	301601
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/09:00333601
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HIV-1 subtyping; non-B subtypes; molecular epidemiology (en)
http://linked.open.../riv/klicoveSlovo	molecular epidemiology HIV-1 subtyping non-B subtypes
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[532D31B77C5E]
http://linked.open...i/riv/nazevZdroje	Central European Journal of Public Health
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Monitoring of HIV/AIDS spread in the Czech Republic
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Reiniš, Milan Malý, M. Brůčková, M. Linka, M. Stanková, M. Vandasová, J.
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	1210-7778
number of pages	3 (xsd:int)

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