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| rdf:type
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| Description
| - Speciační geny omezují pohyb genů mezi vznikajícím druhem a příbuznými taxony. Před třiceti lety jsme mapovali savčí speciační gen hybrid sterility 1 (Hst1) u mezidruhových hybridů myši domácí. Zde identifikujeme tento gen jako prdm9, gen kódující trimetyl tránsferázu lyzinu 4 na histonu 3. Obnovili jsme plodnost hybridních samců pomocí umělých bakteriálních chromozomů nesoucích Prdm9 z kmene s „fertilní“ Hst1 alelou. Sterilní hybidi vykazují sníženou expresi microrchidia 2B (Morc2b) a neschopnost správné lokalizace gH2AX do sex tělíska v pachytene. Tyto defekty, které jsou přítomné také v Prdm9 nulových mutacích, mizí v přítomnosti Prdm9 transgenu. Identifikace prvního genu hybridní sterility u obratlovců poukazuje na roli epigenetiky ve speciaci a otevírá náhled na síť genů hybridní sterility. (cs)
- Speciation genes restrict gene flow between the incipient species and related taxa. Three decades ago, we mapped a mammalian speciation gene, hybrid sterility 1 (Hst1), in the intersubspecific hybrids of house mouse. Here, we identify this gene as Prdm9, encoding a histone H3 lysine 4 trimethyltransferase. We rescued infertility in male hybrids with bacterial artificial chromosomes carrying Prdm9 from a strain with the “fertility Hst1f allele. Sterile hybrids display down-regulated microrchidia 2B (Morc2b) and fail to compartmentalize gH2AX into the pachynema sex (XY) body. These defects, seen also in Prdm9-null mutants, are rescued by the Prdm9 transgene. Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterility gene network.
- Speciation genes restrict gene flow between the incipient species and related taxa. Three decades ago, we mapped a mammalian speciation gene, hybrid sterility 1 (Hst1), in the intersubspecific hybrids of house mouse. Here, we identify this gene as Prdm9, encoding a histone H3 lysine 4 trimethyltransferase. We rescued infertility in male hybrids with bacterial artificial chromosomes carrying Prdm9 from a strain with the “fertility Hst1f allele. Sterile hybrids display down-regulated microrchidia 2B (Morc2b) and fail to compartmentalize gH2AX into the pachynema sex (XY) body. These defects, seen also in Prdm9-null mutants, are rescued by the Prdm9 transgene. Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterility gene network. (en)
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| Title
| - A mouse speciation gene encodes a meiotic histone H3 methyltransferase
- Myší speciační gen kóduje meiotickou metyl-transferázu histonu H3 (cs)
- A mouse speciation gene encodes a meiotic histone H3 methyltransferase (en)
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| skos:prefLabel
| - A mouse speciation gene encodes a meiotic histone H3 methyltransferase
- Myší speciační gen kóduje meiotickou metyl-transferázu histonu H3 (cs)
- A mouse speciation gene encodes a meiotic histone H3 methyltransferase (en)
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| skos:notation
| - RIV/68378050:_____/09:00318335!RIV09-AV0-68378050
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/09:00318335
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - hybrid sterility; histone H3K4 methyltransferase; Prdm9 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Forejt, Jiří
- Vlček, Čestmír
- Trachtulec, Zdeněk
- Mihola, Ondřej
- Schimenti, J. C.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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