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  • This chapter provides a personal insight into the scientific and social atmosphere in former Czechoslovakia. It covers the period of the rise of Hašek’s immunologic school and application of immunologic tolerance to Rous sarcoma virus (RSV) heterotransmission. These approaches permitted establishment of a new model of mammalian cells transformed by RSV (virogenic XC cells), where the noninfectious viral genome was kept indefinitely as new genetic information (provirus). RSV was rescued from nonpermissive mammalian cells by fusion (complementation) with permissive chicken fibroblasts; this opened the way to understanding virus nonpermissiveness.
  • This chapter provides a personal insight into the scientific and social atmosphere in former Czechoslovakia. It covers the period of the rise of Hašek’s immunologic school and application of immunologic tolerance to Rous sarcoma virus (RSV) heterotransmission. These approaches permitted establishment of a new model of mammalian cells transformed by RSV (virogenic XC cells), where the noninfectious viral genome was kept indefinitely as new genetic information (provirus). RSV was rescued from nonpermissive mammalian cells by fusion (complementation) with permissive chicken fibroblasts; this opened the way to understanding virus nonpermissiveness. (en)
  • Článek obsahuje osobní pohled autora na vědeckou a společenskou atmosféru bývalého Československa. Zabývá se obdobím vzestupu Haškovy imunologické školy a aplikací imunologické tolerance na hetero-přenos viru Rousova sarkomu (RSV). To umožnilo vytvořit nový model savčích buněk transformovaných RSV (virogenních XC buněk), kde neinfekční virový genom je přítomen jako nová genetická informace (provirus). RSV bylo však možno získat ze savčích nepermisivních buněk jejich fúzí s permisivními kuřecími fibroblasty. To otevřelo cestu k porozumění nepermisivity vůči retrovirové infekci. (cs)
Title
  • Twists and turns in life and science. Foundation Series in Cancer Research
  • Twists and turns in life and science. Foundation Series in Cancer Research (en)
  • Klikaté cesty života a vědy. Zakladatelská série výzkumu rakoviny (cs)
skos:prefLabel
  • Twists and turns in life and science. Foundation Series in Cancer Research
  • Twists and turns in life and science. Foundation Series in Cancer Research (en)
  • Klikaté cesty života a vědy. Zakladatelská série výzkumu rakoviny (cs)
skos:notation
  • RIV/68378050:_____/08:00097944!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 1;32
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50520514), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 400928
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/08:00097944
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cancer; oncogene; src (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [21EFE032EAAC]
http://linked.open...i/riv/nazevZdroje
  • Advances in Cancer Research
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 99
http://linked.open...iv/tvurceVysledku
  • Svoboda, Jan
http://linked.open...n/vavai/riv/zamer
issn
  • 0065-230X
number of pages
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