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rdf:type
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Description
| - The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis.
- The chemokine receptor CCR2 is highly expressed on monocyes and considered a promising target for treatment of rheumatoid arthritis. However, blockade of CCR2 with monoclonal antibody during progression of collagen-induced arthritis results in massive aggravation of the disease. In this study we investigated vhy CCR2 antibodies have proinflammatory effects, how these effects can be avoided, and whether CCR2+ monocytes are useful targets in the treatment of arthritis. (en)
- Chemokinový receptor CCR2 je vysoce exprimován na monocytech a zdá se být slibným terčem pro léčbu reumatické arthritidy. Blokování CCR2 monoklonální protilátkou při arthritidě vyvolané kolagenem však vede k masivnímu zhoršení této choroby. V této studii jsme sledovali, proč protilátky CCR2+ mají prozánětlivé účinky, jak se těmto účinkům lze vyhnout a zda jsou monocyty CCR2+ dobrými terči pro léčbu arthritidy. (cs)
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Title
| - Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis
- Cílení Gr-1+,CCR2+ monocytů u arthritidy vyvolané kolagenem (cs)
- Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis (en)
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skos:prefLabel
| - Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis
- Cílení Gr-1+,CCR2+ monocytů u arthritidy vyvolané kolagenem (cs)
- Targeting of Gr-1+,CCR2+ monocytes in collagen-induced arthritis (en)
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skos:notation
| - RIV/68378050:_____/07:00097943!RIV08-AV0-68378050
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00097943
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - arthritis; CCR2; monocytes (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Plachý, Jiří
- Gomez, M. R.
- Cihak, J.
- Mack, M.
- Stangassinger, M.
- Talke, Y.
- Denzel, A.
- Niedermeier, M.
- Brühl, H.
- Luckow, B.
- Kunz-Schughart, L.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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