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| Description
| - In this study, we have investigated whether the flavonoid quercetin could sensitize human colon adenocarcinoma cell lines to TRAIL-induced apoptosis. Quercetin enhanced TRAIL-induced apoptosis by causing the redistribution of DR4 and DR5 into lipid rafts. Nystatin, a cholesterol-sequestering agent, prevented quercetin-induced clustering of death receptors and sensitization to TRAIL-induced apoptosis in colon adenocarcinoma cells. Our experiments show that quercetin, in combination with TRAIL, triggered the mitochondrial-dependent death pathway, as shown by Bid cleavage and the release of cytochrome c to the cytosol. Together, our findings propose that quercetin, through its ability to redistribute death receptors at the cell surface, facilitates death-inducing signaling complex formation and activation of caspases.
- In this study, we have investigated whether the flavonoid quercetin could sensitize human colon adenocarcinoma cell lines to TRAIL-induced apoptosis. Quercetin enhanced TRAIL-induced apoptosis by causing the redistribution of DR4 and DR5 into lipid rafts. Nystatin, a cholesterol-sequestering agent, prevented quercetin-induced clustering of death receptors and sensitization to TRAIL-induced apoptosis in colon adenocarcinoma cells. Our experiments show that quercetin, in combination with TRAIL, triggered the mitochondrial-dependent death pathway, as shown by Bid cleavage and the release of cytochrome c to the cytosol. Together, our findings propose that quercetin, through its ability to redistribute death receptors at the cell surface, facilitates death-inducing signaling complex formation and activation of caspases. (en)
- V této studii jsme analyzovali, zda flavonoid quercetin může zvýšit citlivost lidských střevních adenokarcinomových buněčných linií ke TRAILem indukované apoptóze. Quercetin zýšil TRAILem indukovanou apoptózu strupu přerozdělením DR4 a DR5 do lipidických mikrodomén. Nystatin inhiboval quercetinem indukované shlukování %22death%22 receptorů a zcitlivění adenokarcinomových buněk k TRAILem indukované apoptóze. Naše experimenty také prokazují, že quercetin, v kombinaci s TRAILem, aktivoval mitochondriální apoptózu, což prokazuje štěpení proteinu Bid a uvolnění cytochromu c do cytosolu. Celkově naše nálezy naznačují, že quercetin, prostřednictvím své schopnosti přerozdělovat %22death%22 receptory v buněčném povrchu, usnadní vznik smrt indukujícího signálního komplexu a aktivace kaspáz. (cs)
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| Title
| - Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
- Quercetin zvyšuje TRAILem vyvolanou apoptózu u buněk karcinomu kolonu indukcí shlukování %22death%22 receptorů v lipidických mikrodoménách. (cs)
- Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts (en)
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| skos:prefLabel
| - Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts
- Quercetin zvyšuje TRAILem vyvolanou apoptózu u buněk karcinomu kolonu indukcí shlukování %22death%22 receptorů v lipidických mikrodoménách. (cs)
- Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts (en)
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| skos:notation
| - RIV/68378050:_____/07:00094860!RIV08-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0506), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00094860
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - TRAIL; apoptosis; lipid rafts (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Molecular Cancer Therapeutics
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Anděra, Ladislav
- Pintzas, A.
- Doubravská, Lenka
- Drosopoulos, K. G.
- Psahoulia, F. H.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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