About: Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo     Goto   Sponge   NotDistinct   Permalink

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  • Z primární lidských nádorových epiteliálních buněk byly odvozeny buněčné linie. Primární kultury buněk PAP60 a MIH55byly charakterizovány z hlediska jejich proliferačního potenciálu, transformační kapacity a tumorigenicity jak in vitro, tak in vivo. Inkubace s FasL způsobila v primární PAP60 jen slabou apoptózu, rekombinantní SuperKiller TRAIL účinně indukoval apoptózu jak primárních PAP60 a MIH55, tak I kontrolních buněčných linií Caco-2, HT29 a DLD-1. Expresní analýza %22death%22 receptorů v původní nádorové kultuře před a po vložení do myší a v myších implantátech ukázala zvýšenou expresi receptorů DR4 a DR5, korelující se zýšenou citlivostí k TRAILem indukované apoptóze. In vivo Killer TRAIL potlačil růst implantovaných nádorových buněk. (cs)
  • We derived primary human cancer epithelial cells from colon cancer patients. Characterisation of primary cultures PAP60 and MIH55 determined their highly proliferating advantage, transforming capability and tumorigenicity in vitro and in vivo. Although FASL treatment appeared to cause little apoptosis only in the PAP60 primary culture, increased apoptosis independent of p53 was observed in both primary PAP60 and MIH55 and control cell lines Caco-2, HT29 and DLD-1 after treatment with SuperKiller TRAIL. Expression analysis of death receptors (DR) in the original parental tumours, the primary cultures before and after engraftment as well as the mouse xenografts, revealed a significant upregulation of both DR4 and DR5, which correlated to differences in sensitivity of the cells to TRAIL-induced apoptosis. Treating patient tumour xenograft/SCID mouse models with Killer TRAIL in vivo suppressed tumour growth
  • We derived primary human cancer epithelial cells from colon cancer patients. Characterisation of primary cultures PAP60 and MIH55 determined their highly proliferating advantage, transforming capability and tumorigenicity in vitro and in vivo. Although FASL treatment appeared to cause little apoptosis only in the PAP60 primary culture, increased apoptosis independent of p53 was observed in both primary PAP60 and MIH55 and control cell lines Caco-2, HT29 and DLD-1 after treatment with SuperKiller TRAIL. Expression analysis of death receptors (DR) in the original parental tumours, the primary cultures before and after engraftment as well as the mouse xenografts, revealed a significant upregulation of both DR4 and DR5, which correlated to differences in sensitivity of the cells to TRAIL-induced apoptosis. Treating patient tumour xenograft/SCID mouse models with Killer TRAIL in vivo suppressed tumour growth (en)
Title
  • Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo
  • Nově stabilizované linie tumorigenních primárních buněk lidských nádorů kolonu jsou citlivé k vyvolání apoptózy pomocí TRAIL in vitro a in vivo (cs)
  • Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo (en)
skos:prefLabel
  • Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo
  • Nově stabilizované linie tumorigenních primárních buněk lidských nádorů kolonu jsou citlivé k vyvolání apoptózy pomocí TRAIL in vitro a in vivo (cs)
  • Newly established tumourigenic primary human colon cancer cell lines are sensitive to TRAIL-induced apoptosis in vitro and in vivo (en)
skos:notation
  • RIV/68378050:_____/07:00094844!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 73;84
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 12
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 437268
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/07:00094844
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • TRAIL; apoptosis; colon cancer cell lines (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [D4E073762F9F]
http://linked.open...i/riv/nazevZdroje
  • British Journal of Cancer
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 97
http://linked.open...iv/tvurceVysledku
  • Anděra, Ladislav
  • Oikonomou, E.
  • Pintzas, A.
  • Nasioulas, G.
  • Kothonidis, K.
  • Zografos, G.
http://linked.open...n/vavai/riv/zamer
issn
  • 0007-0920
number of pages
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