| Attributes | Values |
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| rdf:type
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| Description
| - Beta-catenin hraje klíčovou roli při adhezi buněk stejně jako v kanonické signální dráze wnt. Ke studiu role beta-cateninu během očního rozvoje jsme použili podmínečné CRE / loxp myši. Inaktivace beta-cateninu nikterak nepotlačí vznik čočky, ale má za následek abnormální morphogenezi. Naproti tomu, inaktivace beta-cateninu v nosním ectodermu, v oblasti s aktivními wnt signály, má za následek utváření crystallin-pozitivních ectopických čoček. (cs)
- Beta-Catenin plays a key role in cadherin-mediated cell adhesion as well as in canonical Wnt signaling. To study the role of beta-catenin during eye development, we used conditional Cre/loxP system in mouse to inactivate beta-catenin in developing lens and retina. Inactivation of beta-catenin does not suppress lens fate, but instead results in abnormal morphogenesis of the lens. Using BAT-gal reporter mice, we show that beta-catenin-mediated Wnt signaling is notably absent from lens and neuroretina throughout eye development. The observed defect is therefore likely due to the cytoskeletal role of beta-catenin, and is accompanied by impaired epithelial cell adhesion. In contrast, inactivation of beta-catenin in the nasal ectoderm, an area with active Wnt signaling, results in formation of crystallin-positive ectopic lentoid bodies. These data suggest that, outside of the normal lens, beta-catenin functions as a coactivator of canonical Wnt signaling to suppress lens fate.
- Beta-Catenin plays a key role in cadherin-mediated cell adhesion as well as in canonical Wnt signaling. To study the role of beta-catenin during eye development, we used conditional Cre/loxP system in mouse to inactivate beta-catenin in developing lens and retina. Inactivation of beta-catenin does not suppress lens fate, but instead results in abnormal morphogenesis of the lens. Using BAT-gal reporter mice, we show that beta-catenin-mediated Wnt signaling is notably absent from lens and neuroretina throughout eye development. The observed defect is therefore likely due to the cytoskeletal role of beta-catenin, and is accompanied by impaired epithelial cell adhesion. In contrast, inactivation of beta-catenin in the nasal ectoderm, an area with active Wnt signaling, results in formation of crystallin-positive ectopic lentoid bodies. These data suggest that, outside of the normal lens, beta-catenin functions as a coactivator of canonical Wnt signaling to suppress lens fate. (en)
|
| Title
| - Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function
- Abnormální morfogeneze a ektopická tvorba čočky v nepřítomnosti funkce beta-kateninu (cs)
- Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function (en)
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| skos:prefLabel
| - Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function
- Abnormální morfogeneze a ektopická tvorba čočky v nepřítomnosti funkce beta-kateninu (cs)
- Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function (en)
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| skos:notation
| - RIV/68378050:_____/07:00094469!RIV08-AV0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA204/04/1358), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00094469
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Wnt; beta-catenin; gene; lens (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kozmik, Zbyněk
- Krauss, S.
- Machoň, Ondřej
- Láchová, Jitka
- Růžičková, Jana
- Krešlová, Jana
- Piatigorsky, J.
- Kemler, R.
- Wawrousek, E. F.
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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