Attributes | Values |
---|
rdf:type
| |
Description
| - Src family kinase Hck was shown to play a critical role in mast cell activation. Degranulation and cytokine production were reduced in FcepsilonRI-stimulated hck(-/-) mast cells. Lyn activity was increased in hck(-/-) cells, leading to increased phosphorylation of several negative regulators. On the other hand, positive regulatory events, such as activation of Syk, Btk, JNK, p38, Akt, and NF-kappaB, are substantially reduced in hck(-/-) mast cells. Analysis of lyn(-/-)hck(-/-), lyn(-/-)FcepsilonRIbeta(-/-), and hck(-/-)FcepsilonRIbeta(-/-) cells shows that Hck exerts these functions via both Lyn-dependent and Lyn-independent mechanisms. Thus, this study has revealed a hierarchical regulation among SFK members to fine-tune mast cell activation.
- Src family kinase Hck was shown to play a critical role in mast cell activation. Degranulation and cytokine production were reduced in FcepsilonRI-stimulated hck(-/-) mast cells. Lyn activity was increased in hck(-/-) cells, leading to increased phosphorylation of several negative regulators. On the other hand, positive regulatory events, such as activation of Syk, Btk, JNK, p38, Akt, and NF-kappaB, are substantially reduced in hck(-/-) mast cells. Analysis of lyn(-/-)hck(-/-), lyn(-/-)FcepsilonRIbeta(-/-), and hck(-/-)FcepsilonRIbeta(-/-) cells shows that Hck exerts these functions via both Lyn-dependent and Lyn-independent mechanisms. Thus, this study has revealed a hierarchical regulation among SFK members to fine-tune mast cell activation. (en)
- Byla prokázána kritická role kinasy Hck v aktivaci mastocytů. Degranulace a produkce cytokinů byly sníženy u hck(-/-) mastocytů stimulovaných přes FcepsilonRI. Aktivita kinasy Lyn byla u hck(-/-) buněk zvýšená, což vedlo k fosforylaci několika negativních regulátorů. na druhé straně pozitivní regulační děje, jako aktivace Syk, Btk, JNK, p38, Akt, a NF-kappaB, byly v hck(-/-) mastocytech silně sníženy.Analýza of lyn(-/-)hck(-/-), lyn(-/-) FcepsilonRIbeta(-/-), a hck(-/-)FcepsilonRIbeta(-/-) buněk ukázala, že Hck působí prostřednictvím jak Lyn-dependentních tak Lyn-independentních mechanismů. tato studie tedy ukázala hierarchickou regulaci mezi kinasami skupiny Src, která ovlivňuje aktivaci mastocytů. (cs)
|
Title
| - The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
- The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn (en)
- Kinasa Hck z rodiny Src reguluje aktivaci mastocytů potlačováním inhibiční Src kinasy Lyn (cs)
|
skos:prefLabel
| - The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
- The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn (en)
- Kinasa Hck z rodiny Src reguluje aktivaci mastocytů potlačováním inhibiční Src kinasy Lyn (cs)
|
skos:notation
| - RIV/68378050:_____/07:00094043!RIV08-AV0-68378050
|
http://linked.open.../vavai/riv/strany
| |
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| |
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00094043
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| |
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| |
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Hořejší, Václav
- Kawakami, T.
- Hong, H.
- Kawakami, Y.
- Kitaura, J.
- Lowell, C. A.
- Ra, C.
- Xiao, W.
|
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |