About: The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn     Goto   Sponge   NotDistinct   Permalink

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  • Src family kinase Hck was shown to play a critical role in mast cell activation. Degranulation and cytokine production were reduced in FcepsilonRI-stimulated hck(-/-) mast cells. Lyn activity was increased in hck(-/-) cells, leading to increased phosphorylation of several negative regulators. On the other hand, positive regulatory events, such as activation of Syk, Btk, JNK, p38, Akt, and NF-kappaB, are substantially reduced in hck(-/-) mast cells. Analysis of lyn(-/-)hck(-/-), lyn(-/-)FcepsilonRIbeta(-/-), and hck(-/-)FcepsilonRIbeta(-/-) cells shows that Hck exerts these functions via both Lyn-dependent and Lyn-independent mechanisms. Thus, this study has revealed a hierarchical regulation among SFK members to fine-tune mast cell activation.
  • Src family kinase Hck was shown to play a critical role in mast cell activation. Degranulation and cytokine production were reduced in FcepsilonRI-stimulated hck(-/-) mast cells. Lyn activity was increased in hck(-/-) cells, leading to increased phosphorylation of several negative regulators. On the other hand, positive regulatory events, such as activation of Syk, Btk, JNK, p38, Akt, and NF-kappaB, are substantially reduced in hck(-/-) mast cells. Analysis of lyn(-/-)hck(-/-), lyn(-/-)FcepsilonRIbeta(-/-), and hck(-/-)FcepsilonRIbeta(-/-) cells shows that Hck exerts these functions via both Lyn-dependent and Lyn-independent mechanisms. Thus, this study has revealed a hierarchical regulation among SFK members to fine-tune mast cell activation. (en)
  • Byla prokázána kritická role kinasy Hck v aktivaci mastocytů. Degranulace a produkce cytokinů byly sníženy u hck(-/-) mastocytů stimulovaných přes FcepsilonRI. Aktivita kinasy Lyn byla u hck(-/-) buněk zvýšená, což vedlo k fosforylaci několika negativních regulátorů. na druhé straně pozitivní regulační děje, jako aktivace Syk, Btk, JNK, p38, Akt, a NF-kappaB, byly v hck(-/-) mastocytech silně sníženy.Analýza of lyn(-/-)hck(-/-), lyn(-/-) FcepsilonRIbeta(-/-), a hck(-/-)FcepsilonRIbeta(-/-) buněk ukázala, že Hck působí prostřednictvím jak Lyn-dependentních tak Lyn-independentních mechanismů. tato studie tedy ukázala hierarchickou regulaci mezi kinasami skupiny Src, která ovlivňuje aktivaci mastocytů. (cs)
Title
  • The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
  • The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn (en)
  • Kinasa Hck z rodiny Src reguluje aktivaci mastocytů potlačováním inhibiční Src kinasy Lyn (cs)
skos:prefLabel
  • The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn
  • The Src family kinase Hck regulates mast cell activation by suppressing an inhibitory Src family kinase Lyn (en)
  • Kinasa Hck z rodiny Src reguluje aktivaci mastocytů potlačováním inhibiční Src kinasy Lyn (cs)
skos:notation
  • RIV/68378050:_____/07:00094043!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 2511;2519
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 451849
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/07:00094043
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Hck; Lyn; kinasa (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [DD160BB95D51]
http://linked.open...i/riv/nazevZdroje
  • Blood
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 110
http://linked.open...iv/tvurceVysledku
  • Hořejší, Václav
  • Kawakami, T.
  • Hong, H.
  • Kawakami, Y.
  • Kitaura, J.
  • Lowell, C. A.
  • Ra, C.
  • Xiao, W.
http://linked.open...n/vavai/riv/zamer
issn
  • 0006-4971
number of pages
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