About: PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells

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About: PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have described various forms of a novel nuclear PML (promyelocytic leukemia protein) compartment associated with nucleoli that is found under growth-permitting conditions in human mesenchymal stem cells but not in several immortal cell lines. In addition, we found that shut-off of rRNA synthesis causes PML translocation to the surface of segregated nucleoli. Intriguingly, treatment causing premature senescence restores PML binding to nucleoli-derived structures and to the surface of segregated nucleoli in HeLa cells. We have described various forms of a novel nuclear PML (promyelocytic leukemia protein) compartment associated with nucleoli that is found under growth-permitting conditions in human mesenchymal stem cells but not in several immortal cell lines. In addition, we found that shut-off of rRNA synthesis causes PML translocation to the surface of segregated nucleoli. Intriguingly, treatment causing premature senescence restores PML binding to nucleoli-derived structures and to the surface of segregated nucleoli in HeLa cells. (en) Popsali jsme různé formy nového PML (protein promyelocytární leukémie) kompartmentu asociovaného s jadérky, který byl nalezen v lidských mesenchymálních kmenových buňkách, ale nebyl detekován v několika imortalizovaných buněčných liniích. Dále jsme zjistili, že inhibice rRNA syntézy vedla k translokaci PML na povrch segregovaných jadérek. Vazba PML na jadérko v HeLa buňkách byla obnovena ve stavu experimentálně navozené předčasné senescence. (cs)
Title	PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells (en) Vazba proteinu PML na specifické struktury jadérka se v normálních, nádorových a senescentních buňkách liší (cs)
skos:prefLabel	PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells (en) Vazba proteinu PML na specifické struktury jadérka se v normálních, nádorových a senescentních buňkách liší (cs)
skos:notation	RIV/68378050:_____/07:00091154!RIV08-AV0-68378050
http://linked.open.../vavai/riv/strany	56;70
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/03/1210), P(GEDYN/04/E002), P(IAA500390501), P(LC06063), P(LC545), Z(AV0Z50390512), Z(AV0Z5039906), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Nováková, Zora Rossmeislová, Lenka Hozák, Pavel Hodný, Zdeněk Philimonenko, Vlada Dobrovolná, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	441602
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/07:00091154
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	PML nuclear bodies; nucleolus; senescence (en)
http://linked.open.../riv/klicoveSlovo	senescence nucleolus PML nuclear bodies
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[717B5E677D8E]
http://linked.open...i/riv/nazevZdroje	Journal of Structural Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Flurescence microscopy in biological and medical research Functional Organisation of the Cell Control of stress and interferon regulated gene expression by transcription factors, histone modification and nuclear compartmentalization Nuclear compartmentalization of nuclear DNA helicase II in relationship to gene expression and cellular senescence The role of PML in cellular senescence
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	159
http://linked.open...iv/tvurceVysledku	Hozák, Pavel Hodný, Zdeněk Philimonenko, Vlada Nováková, Zora Janderová-Rossmeislová, Lenka Vlasáková, Jana
http://linked.open...n/vavai/riv/zamer	Molekulární, buněčné a systémové mechanizmy závažných onemocnění lidského organizmu, jejich diagnostika, terapie a farmakoterapie Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy
issn	1047-8477
number of pages	5 (xsd:int)

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