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rdf:type
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Description
| - We have described various forms of a novel nuclear PML (promyelocytic leukemia protein) compartment associated with nucleoli that is found under growth-permitting conditions in human mesenchymal stem cells but not in several immortal cell lines. In addition, we found that shut-off of rRNA synthesis causes PML translocation to the surface of segregated nucleoli. Intriguingly, treatment causing premature senescence restores PML binding to nucleoli-derived structures and to the surface of segregated nucleoli in HeLa cells.
- We have described various forms of a novel nuclear PML (promyelocytic leukemia protein) compartment associated with nucleoli that is found under growth-permitting conditions in human mesenchymal stem cells but not in several immortal cell lines. In addition, we found that shut-off of rRNA synthesis causes PML translocation to the surface of segregated nucleoli. Intriguingly, treatment causing premature senescence restores PML binding to nucleoli-derived structures and to the surface of segregated nucleoli in HeLa cells. (en)
- Popsali jsme různé formy nového PML (protein promyelocytární leukémie) kompartmentu asociovaného s jadérky, který byl nalezen v lidských mesenchymálních kmenových buňkách, ale nebyl detekován v několika imortalizovaných buněčných liniích. Dále jsme zjistili, že inhibice rRNA syntézy vedla k translokaci PML na povrch segregovaných jadérek. Vazba PML na jadérko v HeLa buňkách byla obnovena ve stavu experimentálně navozené předčasné senescence. (cs)
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Title
| - PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells
- PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells (en)
- Vazba proteinu PML na specifické struktury jadérka se v normálních, nádorových a senescentních buňkách liší (cs)
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skos:prefLabel
| - PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells
- PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells (en)
- Vazba proteinu PML na specifické struktury jadérka se v normálních, nádorových a senescentních buňkách liší (cs)
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skos:notation
| - RIV/68378050:_____/07:00091154!RIV08-AV0-68378050
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA304/03/1210), P(GEDYN/04/E002), P(IAA500390501), P(LC06063), P(LC545), Z(AV0Z50390512), Z(AV0Z5039906), Z(AV0Z50520514)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00091154
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - PML nuclear bodies; nucleolus; senescence (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Structural Biology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hozák, Pavel
- Hodný, Zdeněk
- Philimonenko, Vlada
- Nováková, Zora
- Janderová-Rossmeislová, Lenka
- Vlasáková, Jana
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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