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| Description
| - Heterozygosity for certain mouse and human chromosomal rearrangements is characterized by the incomplete meiotic synapsis of rearranged chromosomes, by their colocalization with the XY body in primary spermatocytes, and by male-limited sterility. Here, we report on the transcriptional down-regulation of genes within the unsynapsed region of the rearranged mouse chromosome 17, and on the subsequent disturbance of X chromosome inactivation. The partial transcriptional suppression of genes in the unsynapsed chromatin was most prominent prior to the mid-pachytene stage of primary spermatocytes. Later, during the mid-late pachytene, the rearranged autosomes colocalized with the XY body, and the X chromosome failed to undergo proper transcriptional silencing. Our findings provide direct evidence on the MSUC acting at the mRNA level, and implicate that autosomal asynapsis in meiosis may cause male sterility by interfering with meiotic sex chromosome inactivation.
- Heterozygosity for certain mouse and human chromosomal rearrangements is characterized by the incomplete meiotic synapsis of rearranged chromosomes, by their colocalization with the XY body in primary spermatocytes, and by male-limited sterility. Here, we report on the transcriptional down-regulation of genes within the unsynapsed region of the rearranged mouse chromosome 17, and on the subsequent disturbance of X chromosome inactivation. The partial transcriptional suppression of genes in the unsynapsed chromatin was most prominent prior to the mid-pachytene stage of primary spermatocytes. Later, during the mid-late pachytene, the rearranged autosomes colocalized with the XY body, and the X chromosome failed to undergo proper transcriptional silencing. Our findings provide direct evidence on the MSUC acting at the mRNA level, and implicate that autosomal asynapsis in meiosis may cause male sterility by interfering with meiotic sex chromosome inactivation. (en)
- Chromozomální přestavby u lidí a u myší v heterozygotním stavu jsou často charakterizovány neúplnou meiotickou synapsí postižených chromozomů, jejich společnou lokalizací s pohlavním tělískem v primárních spermatocytech a samčí sterilitou. Nyní jsme prokázali, že dochází ke snížení genové exprese translokovaného myšího chromozomu 17 v oblasti asynapse, následované poruchou inaktivace chromozomu X. Částečné umlčení transkripce genů z chromozomu 17 je nejvýraznější u primárních spermatocytů před stadiem %22mid-pachytene%22. Později, během stadia %22mid-late pachytene%22, dochází k vazbě translokovaných autozomů s pohlavním tělískem, která je doprovázena poruchou umlčení chromozomu X. Tato pozorování prokazují, že MSUC (Meiotic Silencing of Unsynapsed Chromatin) účinkuje na úrovni mRNA a zároveň naznačují, že autozomální meiotická asynapse může způsobovat samčí sterilitu zabráněním účinné meiotické inaktivace pohlavních chromozomů. (cs)
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| Title
| - Chromosomal rearrangement interferes with meiotic X chromosome inactivation
- Chromozomální přestavba interferuje s meiotickou inaktivací chromozomu X (cs)
- Chromosomal rearrangement interferes with meiotic X chromosome inactivation (en)
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| skos:prefLabel
| - Chromosomal rearrangement interferes with meiotic X chromosome inactivation
- Chromozomální přestavba interferuje s meiotickou inaktivací chromozomu X (cs)
- Chromosomal rearrangement interferes with meiotic X chromosome inactivation (en)
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| skos:notation
| - RIV/68378050:_____/07:00090940!RIV08-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0520), P(GA301/06/1334), P(GA301/07/1383), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00090940
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - chromosomal translocations; meiotic X chromosome inactivation; spermatogenesis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Forejt, Jiří
- Jansa, Petr
- Homolka, David
- Ivánek, Robert
- Čapková, Jana
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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