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| rdf:type
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| Description
| - TNFalpha, IL-1beta, and IFNgamma up-regulate the cell-surface expression of HLA-E on endothelial cells (EC) in vitro and induce the release of soluble HLA-E (sHLA-E). HLA-E up-regulation protects IFN-gamma-activated ECs from NK-mediated cell lysis, while sHLA-E protects bystander cells. Finally, sHLA-E is not detected in normal sera, and increased serum levels correlate with disease activity in patients with antineutrophil cytoplasmic antibody-associated systemic vasculitis. Thus, HLA-E expression and release of sHLA-E are features of EC activation and emphasize immunoregulatory functions of the endothelium. The present identification of soluble HLA-E molecules may have important implications in understanding the pathogenesis of immune-mediated vascular diseases and for the diagnosis and monitoring of patients.
- TNFalpha, IL-1beta, and IFNgamma up-regulate the cell-surface expression of HLA-E on endothelial cells (EC) in vitro and induce the release of soluble HLA-E (sHLA-E). HLA-E up-regulation protects IFN-gamma-activated ECs from NK-mediated cell lysis, while sHLA-E protects bystander cells. Finally, sHLA-E is not detected in normal sera, and increased serum levels correlate with disease activity in patients with antineutrophil cytoplasmic antibody-associated systemic vasculitis. Thus, HLA-E expression and release of sHLA-E are features of EC activation and emphasize immunoregulatory functions of the endothelium. The present identification of soluble HLA-E molecules may have important implications in understanding the pathogenesis of immune-mediated vascular diseases and for the diagnosis and monitoring of patients. (en)
- TNFalpha, IL-1beta, a IFNgamma up-regulují povrchovou expresi HLA-E na endotheliálních buňkách (EC) in vitro a indukují uvolňování rozpustného HLA-E (sHLA-E). Up-regulace HLA-E chrání EC aktivované IFN-gamma před lýzou NK-buňkami, zatímco sHLA-E chrání okolní buňky. sHLA-E se nenachází v normálních sérech a zvýšené koncentrace korelují s aktivitou onemocnění u pacientů se systemickou vaskulitidou asociovanou s cytoplasmatickými protilátkami. HLA-E exprese a uvolňování sHLA-E jsou charakteristikami aktivace EC a zdůrazňují imunoregulační funkce endothelia. Identifikace rozpustných molekul HLA-E může mít významné důsledky pro porozumění patogeneze imunitních vaskulárních onemocnění a pro diagnosu a monitorování pacientů. (cs)
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| Title
| - Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation
- Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation (en)
- Exprese a uvolňování solubilního HLA-E jako imunoregulační charakteristika aktivace endotheliálních buněk (cs)
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| skos:prefLabel
| - Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation
- Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation (en)
- Exprese a uvolňování solubilního HLA-E jako imunoregulační charakteristika aktivace endotheliálních buněk (cs)
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| skos:notation
| - RIV/68378050:_____/07:00085123!RIV08-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/07:00085123
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Hamidou, M.
- Hořejší, Václav
- Charreau, B.
- Soulillou, J. P.
- Coupel, S.
- Moreau, A.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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