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| Description
| - In spite of success in molecular medicine, neoplastic disease remains a serious problem. Cancer cells, albeit of clonal origin, mutate so that they escape established treatments, resulting in the fatal outcome of current therapies. Moreover, there are types of cancer, such as mesotheliomas, that cannot be treated at present. A novel group of clinically interesting anticancer drugs are promising as selective anticancer drugs. These compounds, epitomised by alpha-tocopheryl succinate, comprise redox-silent analogues of vitamin E that have been shown to suppress several types of cancer in animal models, including breast, colon and lung cancer as well as mesotheliomas and melanomas, while being nontoxic to normal cells and tissues. It is now proven that the strong anticancer effect of vitamin E analogues stems from their propensity to induce selective apoptosis in malignant cells. The results point to vitamin E analogues as promising agents applicable to different types of tumours.
- In spite of success in molecular medicine, neoplastic disease remains a serious problem. Cancer cells, albeit of clonal origin, mutate so that they escape established treatments, resulting in the fatal outcome of current therapies. Moreover, there are types of cancer, such as mesotheliomas, that cannot be treated at present. A novel group of clinically interesting anticancer drugs are promising as selective anticancer drugs. These compounds, epitomised by alpha-tocopheryl succinate, comprise redox-silent analogues of vitamin E that have been shown to suppress several types of cancer in animal models, including breast, colon and lung cancer as well as mesotheliomas and melanomas, while being nontoxic to normal cells and tissues. It is now proven that the strong anticancer effect of vitamin E analogues stems from their propensity to induce selective apoptosis in malignant cells. The results point to vitamin E analogues as promising agents applicable to different types of tumours. (en)
- Přes úspěchy v molekulární medicíně, neoplastické choroby zůstávají vážným problémem. Rakovinné buňky, ačkoliv klonálního původu, mutují tak, že unikají použité terapii s fatálními důsledky. Navíc, vyskytují se typy rakoviny, jako mesoteliomy, které jsou v současnosti neléčitelné vůbec. Nová skupina klinicky zajímavých protirakovinných látek se jeví slibnou jakožto selektivně působící. Tyto látky, redoxně neaktivní analogy vitaminu E, jejichž představitelem je alfa-tokoferylsukcinát, potlačují několik typů rakoviny ve zvířecích modelech, včetně rakoviny prsu, tlustého střeva a plic, právě tak jako mesoteliomy a melanomy a jsou přitom netoxické pro normální buňky a tkáně. Je nyní prokázáno, že silný protirakovinný účinek těchto analogů vitaminu E vychází z jejich schopnosti indukovat selektivně apoptózu v maligních buňkách. Výsledky svědčí pro to, že deriváty vitaminu E představují slibné prostředky aplikovatelné na různé typy nádorů. (cs)
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| Title
| - Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate
- Analogy vitaminu E jako protirakovinné prostředky: lekce ze studia použivajícího alfa-tokoferylsukcinát (cs)
- Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate (en)
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| skos:prefLabel
| - Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate
- Analogy vitaminu E jako protirakovinné prostředky: lekce ze studia použivajícího alfa-tokoferylsukcinát (cs)
- Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate (en)
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| skos:notation
| - RIV/68378050:_____/06:00051204!RIV07-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/06:00051204
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - apoptosis; mitochondria; cancer treatment (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Molecular Nutrition & Food Research
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Neužil, Jiří
- Tomasetti, M.
- Dong, L.
- Zhao, Y.
- Wu, K.
- Wang, X. F.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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