About: Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis

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About: Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We evaluated the ability of alpha-tocopheryl succinate (a-TOS) to sensitise TRAIL-resistant malignant mesothelioma (MM) cells to TRAIL-induced apoptosis. We show that alpha-TOS activates expression of DR4/DR5 in a p53-dependent manner and re-establishes sensitivity of resistant MM cells to TRAIL-mediated apoptosis, as documented in p53wt MM cells but not in their p53null counterparts. MM cells selected for TRAIL resistance expressed low cell surface levels of DR4 and DR5. Treatment with sub-lethal doses of a-TOS restored expression of DR4 and DR5. The ability of a-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli. We evaluated the ability of alpha-tocopheryl succinate (a-TOS) to sensitise TRAIL-resistant malignant mesothelioma (MM) cells to TRAIL-induced apoptosis. We show that alpha-TOS activates expression of DR4/DR5 in a p53-dependent manner and re-establishes sensitivity of resistant MM cells to TRAIL-mediated apoptosis, as documented in p53wt MM cells but not in their p53null counterparts. MM cells selected for TRAIL resistance expressed low cell surface levels of DR4 and DR5. Treatment with sub-lethal doses of a-TOS restored expression of DR4 and DR5. The ability of a-TOS to modulate expression of pro-apoptotic genes may play a role in sensitisation of tumour cells to immunological stimuli. (en) Alfa-tokoferol sukcinát (vitamin E sukcinát, a-TOS) zvyšuje citlivost mesotheliomálních nádorových buněk k apoptóze indukované cytotoxickým ligandem TRAIL. a-TOS zvyšuje expresi proapoptotických TRAILových receptorů DR4/DR5 v závislosti na p53. Mesotheliomální buňky rezistentní k TRAILu mají nízkou expresi DR4/DR5, kterou lze zvýšit předinkubací se subletálními dávkami a-TOS. (cs)
Title	Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis Alfa-tokoferol sukcinát vyvolává expresi DR4 a DR5 cestou závislou na p53: implikace pro sensitizaci rezistentních nádorových buněk k apoptóze vyvolané prostřednictvím TRAIL (cs) Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis (en)
skos:prefLabel	Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis Alfa-tokoferol sukcinát vyvolává expresi DR4 a DR5 cestou závislou na p53: implikace pro sensitizaci rezistentních nádorových buněk k apoptóze vyvolané prostřednictvím TRAIL (cs) Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis (en)
skos:notation	RIV/68378050:_____/06:00047784!RIV07-MSM-68378050
http://linked.open.../vavai/riv/strany	1925;1931
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA5052001), P(LN00A026), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Anděra, Ladislav Neužil, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	464630
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/06:00047784
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	malignant mesothelioma; TRAIL; alpha-TOS (en)
http://linked.open.../riv/klicoveSlovo	malignant mesothelioma TRAIL alpha-TOS
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[4EA7E8345171]
http://linked.open...i/riv/nazevZdroje	FEBS Letters
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology Characterization and potential therapeutical use of TRAIL-mediated apoptosis
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	580
http://linked.open...iv/tvurceVysledku	Alleva, R. Anděra, Ladislav Borghi, B. Neužil, Jiří Tomasetti, M. Procopio, A.
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0014-5793
number of pages	7 (xsd:int)

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