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| rdf:type
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| Description
| - Tato studie srovnávává cytotoxicitu a transport paclitaxel a docetaxelu s novými taxany u lidských buněk nádorů prsu. Tyto zkoumané buněčné linie se liší v expresi membránových ABC transportérů. Na základě reverzní transkripční polymerázy bylo odhaleno, že buňky NCI/ADR-RES exprimují vyšší hladinu P glycoproteinu na úrovni mRNA, který chybí u buněk MDA-MB-435, u nich byla zvýšená hladina MRP2. Buňky NCI/ADR/RES jsou hodně rezistentnější vúči paclitaxelu a docetaxelu než buňky MDA-MB-435, ale obě linie podobně senzitivní vúči novým taxanům. Buňky NCI/ADR-RES absorbují přibližně 20krát méně [14C]paclitaxelu, 7 krát méně docetaxelu a přibližně stejně nových taxanů jako buňky MDA-MB-435. SB-T-1103 a SB-T-1216 neovlivňují transport paclitaxelu, ale SB-T-1214 snižuje uptake u obou buňěčných linií. To vede k závěru, že nové taxany nejsou inhibitory P glykoproteinu. (cs)
- This study compared cytotoxicity and transport of paclitaxel and docetaxel with novel taxanes in human breast cancer cells. The cell lines examined differ expression of ABC membrane transporters. Reverse transcription-polymerase chain reaction revealed that NCI/ADR-RES cells expressed high levels of P-glycoprotein mRNA, which was absent in MDA-MB-435 cells, while the opposite was true for MRP2 mRNA. NCI/ADR-RES cells were more resistant to paclitaxel and to docetaxel than MDA-MB-435 cells, but almost equally sensitive to novel taxanes. This complied with the fact that NCI/ADR-RES cells absorbed almost 20-fold less [14C]paclitaxel, about 7-fold less docetaxel, and almost equal amounts of SB-T-1103, SB-T-1214, and SB-T-1216 as the MDA-MB-435 cells. SB-T-1103 and SB-T-1216 did not influence transport of paclitaxel, but SB-T-1214 decreased [14C]paclitaxel uptake in both cell lines indicating inhibition of uptake. This suggests that the novel taxanes are not inhibitors of P-glycoprotein.
- This study compared cytotoxicity and transport of paclitaxel and docetaxel with novel taxanes in human breast cancer cells. The cell lines examined differ expression of ABC membrane transporters. Reverse transcription-polymerase chain reaction revealed that NCI/ADR-RES cells expressed high levels of P-glycoprotein mRNA, which was absent in MDA-MB-435 cells, while the opposite was true for MRP2 mRNA. NCI/ADR-RES cells were more resistant to paclitaxel and to docetaxel than MDA-MB-435 cells, but almost equally sensitive to novel taxanes. This complied with the fact that NCI/ADR-RES cells absorbed almost 20-fold less [14C]paclitaxel, about 7-fold less docetaxel, and almost equal amounts of SB-T-1103, SB-T-1214, and SB-T-1216 as the MDA-MB-435 cells. SB-T-1103 and SB-T-1216 did not influence transport of paclitaxel, but SB-T-1214 decreased [14C]paclitaxel uptake in both cell lines indicating inhibition of uptake. This suggests that the novel taxanes are not inhibitors of P-glycoprotein. (en)
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| Title
| - Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells
- Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells (en)
- Transport a cytotoxicita paclitaxelu, docetaxelu a nových taxanů u lidských buněk nádorů prsu (cs)
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| skos:prefLabel
| - Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells
- Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells (en)
- Transport a cytotoxicita paclitaxelu, docetaxelu a nových taxanů u lidských buněk nádorů prsu (cs)
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| skos:notation
| - RIV/68378050:_____/05:00027660!RIV06-AV0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA305/04/0403), P(NL7567), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00027660
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - taxanes; uptake; ABC transporters (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Naunyn-Schmiedeberg's Archiv of Pharmacology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kovář, Jan
- Truksa, Jaroslav
- Chen, J.
- Ehrlichová, Marie
- Ojima, I.
- Gut, I.
- Václavíková, R.
- Kuznetsova, L. V.
- Pepe, A.
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| http://linked.open...n/vavai/riv/zamer
| |
| issn
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| number of pages
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