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Description
  • Production of nitric oxide (NO) by graft infiltrating macrophages has been suggested as an important effector mechanism of allograft rejection. Whether NO plays a role in rejection of skin xenografts has not been documented. Here we described a suppressive molecule of molecular mass of 67 kDa which is produced by rejected rat skin xenografts and which selectively inhibits the iNOS activity in graft infiltrating macrophages. Therefore, NO does not play a significant role in rejection of rat skin xenografts as it does in the case of allograft rejection.
  • Production of nitric oxide (NO) by graft infiltrating macrophages has been suggested as an important effector mechanism of allograft rejection. Whether NO plays a role in rejection of skin xenografts has not been documented. Here we described a suppressive molecule of molecular mass of 67 kDa which is produced by rejected rat skin xenografts and which selectively inhibits the iNOS activity in graft infiltrating macrophages. Therefore, NO does not play a significant role in rejection of rat skin xenografts as it does in the case of allograft rejection. (en)
  • Produkce oxidu dusnatého (NO) makrofágy infiltrujícími transplantát je považována za důležitý efektorový mechanismus při rejekci alotransplantátů. Zda tento mechanismus hraje roli při rejekci xenotransplantátů není dosud známo. V této práci jsme popsali supresivní molekulu o hmotnosti 67 kDa, která je produkována rejekovaným xenotransplantátem krysí kůže. Tato molekula selektivně inhibuje aktivitu iNOS v makrofázích infiltrovaných v transplantátu. V tomto případě nemůže NO hrát důležitou roli při rejekci xenotranspalntátu krysí kůže, tak jak je tomu v případě alogenní rejekce. (cs)
Title
  • The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells
  • The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells (en)
  • Aktivita indukovatelné NO synthasy v rejekovaných kožních xenotransplantátech je selektivně inhibována faktorem produkovaným transplantovanými buňkami (cs)
skos:prefLabel
  • The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells
  • The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells (en)
  • Aktivita indukovatelné NO synthasy v rejekovaných kožních xenotransplantátech je selektivně inhibována faktorem produkovaným transplantovanými buňkami (cs)
skos:notation
  • RIV/68378050:_____/05:00025577!RIV06-AV0-68378050
http://linked.open.../vavai/riv/strany
  • 227;234
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GD310/03/H147), P(GP310/02/D162), P(KSK5020115), P(ME 300), P(NR7816), Z(AV0Z50110509), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 511318
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/05:00025577
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • inducible nitric oxide synthase production; nitric oxide; suppressive molecule (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DK - Dánské království
http://linked.open...ontrolniKodProRIV
  • [C324060D38C7]
http://linked.open...i/riv/nazevZdroje
  • Xenotransplantation
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 12
http://linked.open...iv/tvurceVysledku
  • Svoboda, Petr
  • Železná, Blanka
  • Holáň, Vladimír
  • Krulová, Magdalena
  • Matoušek, Petr
  • Zajícová, Alena
  • Pindjáková, Jana
http://linked.open...n/vavai/riv/zamer
issn
  • 0908-665X
number of pages
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