About: Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription

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About: Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Předpokládá se, že prozánětlivá odpověď a hyperaktivita HPA osy je zahrnuta v patogenesi deprese. Již dříve jsme zjistili, že antidepresiva inhibují v in vitro podmínkách funkci glukokortikoidního receptoru (GR). Zkoumali jsme vliv LPS na imipramin- nebo fluoxetinem indukovanou inhibici GR ovlivněné genové transkripce ve fibroblastech. Výsledky naznačují, že prozánětlivá agens usnadňují antidepresivy indukovanou inhibici funkce GR. (cs) It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function. It has been hypothesized that pro-inflammatory response and hyperactivity of HPA axis are involved in the pathogenesis of depression. Previously we found that antidepressants inhibited glucocoticoid receptor (GR) function under the in vitro conditions. We investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells. The data suggested that pro-inflammatory agents facilitate antidepressant-induced inhibition of glucocorticoid receptor function. (en)
Title	Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription (en) Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem (cs)
skos:prefLabel	Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription Effect of lipopolysaccharide and antidepressant drugs on glucocorticoid receptor-mediated gene transcription (en) Vliv lipopolysacharidu a antidepresiv na genovou transkripci zprostředkovanou glukokortikoidovým receptorem (cs)
skos:notation	RIV/68378050:_____/05:00025555!RIV06-AV0-68378050
http://linked.open.../vavai/riv/strany	540;544
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Holáň, Vladimír Zajícová, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	519348
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/05:00025555
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	glucocorticoid receptor; antidepressant drugs; interleukin-6 (en)
http://linked.open.../riv/klicoveSlovo	interleukin-6 antidepressant drugs glucocorticoid receptor
http://linked.open...odStatuVydavatele	PL - Polská republika
http://linked.open...ontrolniKodProRIV	[D8979205554A]
http://linked.open...i/riv/nazevZdroje	Pharmacological Reports
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	57
http://linked.open...iv/tvurceVysledku	Holáň, Vladimír Zajícová, Alena Basta-Kaim, A. Budziszewska, B. Kubera, M. Leskiewicz, M. Tetich, M. Lasoń, W. Jaworska, L. Otczyk, M.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1734-1140
number of pages	5 (xsd:int)

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