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| Description
| - TGF-b must be activated from the latent form (LTGF-b) to induce biological responses. We report activation of TGF-b by co-operation of the mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) and the u-PAR (CD87). Endothelial cells express CD222 and CD87 in a membrane complex; the association of these two receptors is essential for the release of active TGF-b in the transduced mouse fibroblast. Smooth-muscle cells, which express CD222 and CD87 at similar density to endothelial cells but not in complexed form, do not activate TGF-b. Mini-plasminogen is a high-affinity ligand for CD222 and is essential for the activation of TGF-b by the CD87-CD222 complex to induce apoptosis in endothelial cells. This specific mechanism of TGF-b-mediated apoptosis in endothelial cells is thus a potential novel target for treatment of pathological vascular disorders (e.g. tumor angiogenesis).
- TGF-b must be activated from the latent form (LTGF-b) to induce biological responses. We report activation of TGF-b by co-operation of the mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) and the u-PAR (CD87). Endothelial cells express CD222 and CD87 in a membrane complex; the association of these two receptors is essential for the release of active TGF-b in the transduced mouse fibroblast. Smooth-muscle cells, which express CD222 and CD87 at similar density to endothelial cells but not in complexed form, do not activate TGF-b. Mini-plasminogen is a high-affinity ligand for CD222 and is essential for the activation of TGF-b by the CD87-CD222 complex to induce apoptosis in endothelial cells. This specific mechanism of TGF-b-mediated apoptosis in endothelial cells is thus a potential novel target for treatment of pathological vascular disorders (e.g. tumor angiogenesis). (en)
- Tato práce popisuje aktivaci cytokinu TGF-b kooperací receptorů: mannose-6-phosphate/insulin-like-growth-factor-II receptor (CD222) a u-PAR (CD87). Endotheliální buňky exprimují CD222 a CD87 v membránovém komplexu; asociace těchto receptorů je zásadně důležitá pro uvolnění aktivního TGF-b v transdukovaných myších fibroblastech. Buňky hladkého svalstva, které také exprimují CD222 a CD87, ale v nekomplexní formě, neaktivují TGF-b. Mini-plasminogen je vysokoafinním ligandem CD222 a je zásadně důležitý pro aktivaci TGF-b komplexem CD87-CD222, potřebnou k indukci apoptosy endotheliálních buněk. Tento mechanismus představuje nový potenciální cíl pro léčbu patologických vaskulárních dějů (např. nádorová angiogenesa). (cs)
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| Title
| - TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen
- Apoptóza vyvolaná v endoteliálních buňkách TGF-beta zprostředkovaná M6P/IGFII-R a mini-plasminogenem (cs)
- TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen (en)
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| skos:prefLabel
| - TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen
- Apoptóza vyvolaná v endoteliálních buňkách TGF-beta zprostředkovaná M6P/IGFII-R a mini-plasminogenem (cs)
- TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen (en)
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| skos:notation
| - RIV/68378050:_____/05:00021377!RIV06-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00021377
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - apoptosis; TGF-beta; mini-plasminogen (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Hořejší, Václav
- Leksa, V.
- Schiller, H. B.
- Stockinger, H.
- Steinlein, P.
- Binder, B. R.
- Godar, S.
- Weidle, U. H.
- Fuertbauer, E.
- Muhammad, A.
- Slezakova, K.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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