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| rdf:type
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| Description
| - Klonovali jsme gen pro receptor ASLV skupiny C (tvc) a identifikovali receptor Tvc. Gen tvc byl identifikován na umělém bakteriálním chromozomu obsahujícím část kuřecího chromozomu 28, která zajišťuje citlivost vůči infekci ASLV(C), a kóduje protein o 488 aminokyselinách velmi úzce příbuzný savčím butyrofilinům. Klonovali jsme cDNA kódující Tvc, které zajišťují citlivost vůči infekci viry podskupiny C v kuřecích buňkách odolných proti infekci ASLV(C) a v savčích buňkách, které normálně neexprimují funkční receptory ASLV. Navíc poté, co byly obě alely tvc přerušeny homologní rekombinací, byly normálně citlivé kuřecí buňky DT40 odolné vůči infekci ASLV(C). Tvc váže obalové glykoproteiny ASLV(C) v nízkonanomolární afinitou podobnou jako u vazby Tva a Tvb na jejich obalové proteiny. U kuřat linie L15 jsme identifikovali mutaci v genu tvc, která vysvětluje, proč je tato linie odolná vůči infekci ASLV(C). (cs)
- We cloned the subgroup C ASLV receptor gene (tvc) and identified the Tvc receptor. The tvc gene was identified on a bacterial artificial chromosome containing a portion of chicken chromosome 28 that conferred susceptibility to ASLV(C) infection and encodes a 488-amino-acid protein most closely related to mammalian butyrophilins. We cloned cDNAs encoding Tvc that confer susceptibility to infection by subgroup C viruses in chicken cells resistant to ASLV(C) infection and in mammalian cells that do not normally express functional ASLV receptors. In addition, normally susceptible chicken DT40 cells were resistant to ASLV(C) infection after both tvc alleles were disrupted by homologous recombination. Tvc binds the ASLV(C) envelope glycoproteins with low-nanomolar affinity, similar to that of binding of Tva and Tvb with their envelope glycoproteins. We identified a mutation in the tvc gene in line L15 chickens that explains why this line is resistant to ASLV(C) infection.
- We cloned the subgroup C ASLV receptor gene (tvc) and identified the Tvc receptor. The tvc gene was identified on a bacterial artificial chromosome containing a portion of chicken chromosome 28 that conferred susceptibility to ASLV(C) infection and encodes a 488-amino-acid protein most closely related to mammalian butyrophilins. We cloned cDNAs encoding Tvc that confer susceptibility to infection by subgroup C viruses in chicken cells resistant to ASLV(C) infection and in mammalian cells that do not normally express functional ASLV receptors. In addition, normally susceptible chicken DT40 cells were resistant to ASLV(C) infection after both tvc alleles were disrupted by homologous recombination. Tvc binds the ASLV(C) envelope glycoproteins with low-nanomolar affinity, similar to that of binding of Tva and Tvb with their envelope glycoproteins. We identified a mutation in the tvc gene in line L15 chickens that explains why this line is resistant to ASLV(C) infection. (en)
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| Title
| - The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily
- Receptor pro ptačí sarkomové a leukózové viry podskupiny C Tvc je příbuzný savčím butyrofilinům, členům nadrodiny imunoglobuilinů (cs)
- The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily (en)
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| skos:prefLabel
| - The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily
- Receptor pro ptačí sarkomové a leukózové viry podskupiny C Tvc je příbuzný savčím butyrofilinům, členům nadrodiny imunoglobuilinů (cs)
- The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily (en)
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| skos:notation
| - RIV/68378050:_____/05:00020887!RIV06-AV0-68378050
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA523/04/0489), Z(AV0Z50520514)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00020887
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - retrovirus receptor; avian sarcoma and leukosis viruses; butyrophilin (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Plachý, Jiří
- Hejnar, Jiří
- Geryk, Josef
- Šenigl, Filip
- Pajer, Petr
- Stepanets, Volodymyr
- Elleder, Daniel
- Federspiel, M. J.
- Melder, D. C.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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