About: Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide

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About: Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed. The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed. (en) Monoklonální protilátka 1696, jejíž tvorbu vyvolává proteáza HIV-1, potlačuje aktivitu proteáz HIV-1 i HIV-2, s inhibičními konstantami v nízkém nanomolárním rozmezí. Tato protilátka křížově reaguje s peptidy odvozenými od N-koncové oblasti obou proteáz. Byla určena krystalová struktura rekombinantního jednořetězcového Fv fragmentu 1696 v komplexu s N-koncovým peptidem proteázy HIV-2 s rozlišením 1,88A. Byly porovnány vzájemné reakce tohoto peptidu s scFv1696 a dříve určené struktury scFv1696 v komplexu s odpovídajícím peptidem proteázy HIV-1. Je diskutován původ křížové reakce monoklonální protilátky 1696 s proteázami HIV. (cs)
Title	Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide (en) Krystalová struktura křížově reagujícího komplexu protilátky proti HIV-1 proteáze a peptidu proteázy HIV-2 (cs)
skos:prefLabel	Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide (en) Krystalová struktura křížově reagujícího komplexu protilátky proti HIV-1 proteáze a peptidu proteázy HIV-2 (cs)
skos:notation	RIV/68378050:_____/05:00001369!RIV06-AV0-68378050
http://linked.open.../vavai/riv/strany	332;337
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GV203/98/K023), P(KSK5011112)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Řezáčová, Pavlína Brynda, Jiří Hořejší, Magdalena Fábry, Milan Sieglová, Irena Sedláček, Juraj
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	516582
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/05:00001369
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	single-chain Fv fragment; peptide complex; HIV protease (en)
http://linked.open.../riv/klicoveSlovo	HIV protease peptide complex single-chain Fv fragment
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[6E923A7F14D6]
http://linked.open...i/riv/nazevZdroje	Journal of Structural Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and cellular mechanisms of important diseases Protein crystallography analyses of liganded proteinase of human immunodeficiency virus ( HIV ) for design of novel anti - AIDS compounds
http://linked.open...UplatneniVysledku	2005
http://linked.open...v/svazekPeriodika	149
http://linked.open...iv/tvurceVysledku	Brynda, Jiří Fábry, Milan Sieglová, Irena Řezáčová, Pavlína Sedláček, Juraj Hořejší, Magdalena Bentley, G. A. Lescar, J.
issn	1047-8477
number of pages	6 (xsd:int)

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