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| Description
| - We show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cell death in human colon adenocarcinoma cells in a MEK-dependent manner. We also report a prolonged MEK-dependent activation of ERK1/2 and increased c-FOS expression induced by TRAIL in this system. We reveal that transformation of colon cell line Caco-2 by Ki- and mainly Ha-ras oncogenes sensitizes these cells to TRAIL-induced apoptosis by causing specific MEK-dependent up-regulation of DR4 and DR5. These observations taken together reveal that RAS-MEK-ERK1/2 signaling pathway can sensitize cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 and overall imply that TRAIL-based therapeutic strategies using TRAIL agonists could be used in cases of human colon cancers bearing RAS mutations.
- We show that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces cell death in human colon adenocarcinoma cells in a MEK-dependent manner. We also report a prolonged MEK-dependent activation of ERK1/2 and increased c-FOS expression induced by TRAIL in this system. We reveal that transformation of colon cell line Caco-2 by Ki- and mainly Ha-ras oncogenes sensitizes these cells to TRAIL-induced apoptosis by causing specific MEK-dependent up-regulation of DR4 and DR5. These observations taken together reveal that RAS-MEK-ERK1/2 signaling pathway can sensitize cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 and overall imply that TRAIL-based therapeutic strategies using TRAIL agonists could be used in cases of human colon cancers bearing RAS mutations. (en)
- Ukazujeme, že TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) vyvolává buněčnou smrt u buněk adenokarcinomu lidského kolonu cestou závislou na MEK. Ukazujeme dále dlouhodobou aktivaci ERK1/2 a zvýšenou expresi c-FOS vyvolanou v tomto systému pomocí TRAIL. Odhalujeme, že transformace buněčné linie kolonu Caco-2 onkogeny Ki- a zejména Ha-ras způsobuje citlivost těchto buněk vůči apoptóze vyvolané TRAIL specifickým zvýšením exprese DR4 a DR5 závislým na MEK. Z těchto pozorování vyplývá, že signální dráha RAS-MEK-ERK1/2 může způsobit citlivost buněk vůči apoptóze vyvolané TRAIL zvýšením exprese DR4 a DR5, a lze tedy souhrnně říci, že léčebné strategie založené na TRAIL a využívající agonisty TRAIL by mohly být využity pro případy nádorů lidského kolonu vyvolané mutacemi RAS. (cs)
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| Title
| - Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
- Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway (en)
- Transformace onkogenním RAS způsobuje citlivost buněk lidského kolonu vůči apoptóze vyvolané TRAIL zvýšením exprese receptoru smrti 4 a receptoru smrti 5 cestou závislou na MEK (cs)
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| skos:prefLabel
| - Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway
- Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway (en)
- Transformace onkogenním RAS způsobuje citlivost buněk lidského kolonu vůči apoptóze vyvolané TRAIL zvýšením exprese receptoru smrti 4 a receptoru smrti 5 cestou závislou na MEK (cs)
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| skos:notation
| - RIV/68378050:_____/05:00001247!RIV06-AV0-68378050
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(KJB5052407), P(KSK5020115)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/05:00001247
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - TRAIL; Ras; apoptosis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Journal of Biological Chemistry
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Anděra, Ladislav
- Pintzas, A.
- Sasazuki, T.
- Shirasawa, S.
- Čermák, Lukáš
- Drosopoulos, K. G.
- Roberts, M. L.
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| number of pages
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