| Attributes | Values |
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| rdf:type
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| Description
| - Na myším experimentálním modelu napodobujícím lidské karcinomy vyvolané HPV16 jsme zkoumali schopnost buněčných vakcín založených na dendritických bunkách inkubovaných s peptidy odvozenými z lidských onkoproteinů HPV16 E6/E7 vyvolat imunitní odpověď in vitro a vyvolat ochrannou imunitu. V imunizačních/expozičních experimentech jsme našli dobrou korelaci mezi účinností vakcín in vitro, určenou cytotoxickými testy s uvolňováním chrómu, a úrovní ochrany proti nádorovému růstu. Výsledky experimentů in vitro i in vito odhalily, že buněčné vakcíny založené na dendritických buňkách z kostní dřeně pulzovaných s peptidy, které přesahují délku optimální pro vazbu MHC 1. třídy a které obsahují epitop Th, jsou schopné proti MHC I pozitivním nádorům vyvolaným HPV16 vyvolat silnou a ochrannou imunitu založenou na CTL (cs)
- We have investigated the capacity of cellular vaccines based on dendritic cells loaded with human HPV16 E6/E7 oncoprotein-derived peptides to induce immune responses in vitro and to elicit protective immunity in a murine experimental model mimicking human HPV16-associated carcinomas. We have found a good correlation between the vaccine efficacy in vitro, determined by chromium release cytotoxic tests, and the level of protection against tumour growth in immunization-challenge experiments. The results from both in vitro and in vivo experiments revealed that BMDC-based cellular vaccines pulsed with peptides, which exceed the length optimal for binding of the MHC class I and which harbour the Th epitope, are capable to elicit strong and protective CTL-based immunity against HPV16-associated MHC class I positive tumours
- We have investigated the capacity of cellular vaccines based on dendritic cells loaded with human HPV16 E6/E7 oncoprotein-derived peptides to induce immune responses in vitro and to elicit protective immunity in a murine experimental model mimicking human HPV16-associated carcinomas. We have found a good correlation between the vaccine efficacy in vitro, determined by chromium release cytotoxic tests, and the level of protection against tumour growth in immunization-challenge experiments. The results from both in vitro and in vivo experiments revealed that BMDC-based cellular vaccines pulsed with peptides, which exceed the length optimal for binding of the MHC class I and which harbour the Th epitope, are capable to elicit strong and protective CTL-based immunity against HPV16-associated MHC class I positive tumours (en)
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| Title
| - Immunogenicity of dendritic cell-based HPV16 E6/E7 peptide vaccines: CTL activation and protective effects
- Imunogenicita HPV16 E6/E7 peptidových vakcín odvozených z dendritických buněk: aktivace a obranný účinek CTL (cs)
- Immunogenicity of dendritic cell-based HPV16 E6/E7 peptide vaccines: CTL activation and protective effects (en)
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| skos:prefLabel
| - Immunogenicity of dendritic cell-based HPV16 E6/E7 peptide vaccines: CTL activation and protective effects
- Imunogenicita HPV16 E6/E7 peptidových vakcín odvozených z dendritických buněk: aktivace a obranný účinek CTL (cs)
- Immunogenicity of dendritic cell-based HPV16 E6/E7 peptide vaccines: CTL activation and protective effects (en)
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| skos:notation
| - RIV/68378050:_____/04:00108994!RIV/2005/AV0/A23005/N
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA301/01/0985), P(GA301/04/0492), P(KSK5011112), P(NC7148), P(NR7807), Z(AV0Z5052915)
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| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/04:00108994
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - HPV16 E6/E7 peptides; dendritic cells; cytotoxic lymphocytes (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| |
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Reiniš, Milan
- Bieblová, Jana
- Bubeník, Jan
- Indrová, Marie
- Velek, Jiří
- Jandlová, Táňa
- Vonka, V.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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