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rdf:type
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Description
| - Depletion of NK1.1+ cells by repeated i.p. injections of PK136 antibody significantly enhanced growth of MHC class I+ tumours in syngeneic mice. Depletion starting before tumour transplantation substantially accelerated tumour growth; depletion starting on day 7 or 14 after tumour transplantation was without any effect. These results indicate that the NK1.1+ cells play an important inhibitory role during the early phase of the growth of some MHC class I+ tumours. Since the relevant target for NK cells is a \%22missing self\%22 signal, absence of the MHC class I molecules, the NK cells cannot be expected to directly inhibit the growth of the MHC class I+ tumours. The results indicate that the effects of non-NK cells or indirect effects mediated by NK cell interactions and release of cytokines were responsible for the results
- Depletion of NK1.1+ cells by repeated i.p. injections of PK136 antibody significantly enhanced growth of MHC class I+ tumours in syngeneic mice. Depletion starting before tumour transplantation substantially accelerated tumour growth; depletion starting on day 7 or 14 after tumour transplantation was without any effect. These results indicate that the NK1.1+ cells play an important inhibitory role during the early phase of the growth of some MHC class I+ tumours. Since the relevant target for NK cells is a \%22missing self\%22 signal, absence of the MHC class I molecules, the NK cells cannot be expected to directly inhibit the growth of the MHC class I+ tumours. The results indicate that the effects of non-NK cells or indirect effects mediated by NK cell interactions and release of cytokines were responsible for the results (en)
- Deplece buněk NK1.1+ opakovanými i.p. injekcemi protilátky PK136 výrazně posílilo růst MHC I+ nádorů v syngenních myších. Deplece započatá před transplantací nádoru podstatně urychlila jejich růst; deplece započatá 7. či 14. den po transplantaci nádoru neměla žádný účinek. Z těchto výsledků vyplývá, že buňky NK1.1+ hrají důležitou inhibiční úlohu během časné fáze růstu některých MHC I+ nádorů (cs)
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Title
| - The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours
- Úloha buněk NK1.1+ v ochraně proti MHC I+ nádorům vyvolaným HPV16 (cs)
- The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours (en)
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skos:prefLabel
| - The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours
- Úloha buněk NK1.1+ v ochraně proti MHC I+ nádorům vyvolaným HPV16 (cs)
- The role of NK1.1+ cells in the protection against MHC class I+ HPV16-associated tumours (en)
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skos:notation
| - RIV/68378050:_____/04:00108993!RIV/2005/AV0/A23005/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(IAA5052203), P(KSK5011112), P(NC7148), P(NR7807), Z(AV0Z5052915)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/04:00108993
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - HPV16; MHC class I expression; NK1.1+ cells (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Bieblová, Jana
- Bubeník, Jan
- Šímová, Jana
- Jandlová, Táňa
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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