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| Description
| - Malignant mesothelioma (MM) is a fatal type of neoplasia with poor therapeutic prognosis, largely due to resistance to apoptosis. We investigated the apoptotic effect of a-tocopheryl succinate (a-TOS), a strong proapoptotic agent, in combination with the immunological apoptogen TNF-related apoptosis-inducing ligand (TRAIL) on both MM and nonmalignant mesothelial cells, since MM cells show low susceptibility to the clinically intriguing TRAIL. All MM cell lines tested were sensitive to a-TOS-induced apoptosis, and exerted high sensitivity to TRAIL in the presence of subapoptotic doses of the vitamin E analogue. Neither TRAIL or a-TOS alone or in combination caused apoptosis in nonmalignant mesothelial cells. Isobologram analysis of the cytotoxicity assays revealed a synergistic interaction between the two agents in MM cells and their antagonistic effect in nonmalignant mesothelial cells. TRAILinduced apoptosis and its augmentation by a-TOS were inhibited by the caspase-8 inhibitor Z-...
- Malignant mesothelioma (MM) is a fatal type of neoplasia with poor therapeutic prognosis, largely due to resistance to apoptosis. We investigated the apoptotic effect of a-tocopheryl succinate (a-TOS), a strong proapoptotic agent, in combination with the immunological apoptogen TNF-related apoptosis-inducing ligand (TRAIL) on both MM and nonmalignant mesothelial cells, since MM cells show low susceptibility to the clinically intriguing TRAIL. All MM cell lines tested were sensitive to a-TOS-induced apoptosis, and exerted high sensitivity to TRAIL in the presence of subapoptotic doses of the vitamin E analogue. Neither TRAIL or a-TOS alone or in combination caused apoptosis in nonmalignant mesothelial cells. Isobologram analysis of the cytotoxicity assays revealed a synergistic interaction between the two agents in MM cells and their antagonistic effect in nonmalignant mesothelial cells. TRAILinduced apoptosis and its augmentation by a-TOS were inhibited by the caspase-8 inhibitor Z-... (en)
- Maligní mezoteliom (MM) je smrtelný typ neoplasie se špatnou prognózou léčby, zejména díky své odolnosti vůči apoptóze. Studovali jsme apoptotický účinek a-tokoferyl sukcinátu (a-TOS), silného proapoptotického činitele, v kombinaci s imunologickým proapoptogenem TRAIL (ligand vyvolávající apoptózu přibuzný TNF) na buňky MM i nemaligní mezotelové buňky, jelikož buňky MM vykazují nízkou susceptibilitu ke klinicky zajímavému TRAIL. Všechny testované linie MM buněk byly citlivé na apoptózu vyvolanou a-TOS a vykazovaly vysokou citlivost na TRAIL v přítomnosti subapoptotických dávek analoga vitamínu E. Ani TRAIL ani a-TOS, samotný či v kombinaci, nevyvolaly v nemaligních mezotelových buňkách apoptózu. Izobologramová analýza cytotoxických testů ukázala synergistické působení těchto dvou činidel v MM buňkách a jejich antagonistický účinek v nemaligních mezotelových buňkách. Apoptóza vyvolaná TRAIL a její posílení a-TOS byly potlačeny inhibitorem kaspázy 8 Z-IETD-FMK a inhibitorem pro všechn... (cs)
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| Title
| - Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells
- Alfa-tokoferyl sukcinát a TRAIL selektivně spolupůsobí při vyvolání apoptózy u lidských buněk maligního mezoteliomu (cs)
- Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (en)
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| skos:prefLabel
| - Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells
- Alfa-tokoferyl sukcinát a TRAIL selektivně spolupůsobí při vyvolání apoptózy u lidských buněk maligního mezoteliomu (cs)
- Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells (en)
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| skos:notation
| - RIV/68378050:_____/04:00105320!RIV/2005/AV0/A23005/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(IAA5052001), P(LN00A026), Z(AV0Z5052915)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/04:00105320
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - TRAiL, a-TOS, apoptosis (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - British Journal of Cancer
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Alleva, R.
- Anděra, Ladislav
- Tomasetti, M.
- Moretti, S.
- Neužil, J.
- Procopio, A.
- Rippo, M. R.
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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