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Description
  • Depending on the excess of ligand used for complex formation, the HIV-protease complexed with a novel phenylnorstatine inhibitor forms crystal either hexagonal (P6(1)) or orthorhombic (P2(1)2(1)) symetry. The orthorhombic form shows an unusual complexity of crystal packing: in addition to one inhibitor molecule that is bound to the enzyme active site, the second inhibitor molecule is bound as an outer ligand at the protein interface
  • Depending on the excess of ligand used for complex formation, the HIV-protease complexed with a novel phenylnorstatine inhibitor forms crystal either hexagonal (P6(1)) or orthorhombic (P2(1)2(1)) symetry. The orthorhombic form shows an unusual complexity of crystal packing: in addition to one inhibitor molecule that is bound to the enzyme active site, the second inhibitor molecule is bound as an outer ligand at the protein interface (en)
  • V závislosti na nadbytku ligandu využitého pro tvorbu komplexu tvoří HIV-proteáza v komplexu s novým fenylnorstatinovým inhibitorem krystalovou hexagonální (P6(1)) nebo ortorombickou (P2(1)2(1)) symetrii. Ortorombická forma vykazuje neobvyklou komplexnost složení krystalu: kromě jedné molekuly inhibitoru vázané na aktivní místo enzymu je druhá molekula inhibitoru vázána na vnější ligand na proteinovém rozhraní (cs)
Title
  • Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex
  • Vazba inhibitoru na proteinové rozhraní v krystalu komplexu HIV-1 proteázy (cs)
  • Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex (en)
skos:prefLabel
  • Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex
  • Vazba inhibitoru na proteinové rozhraní v krystalu komplexu HIV-1 proteázy (cs)
  • Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex (en)
skos:notation
  • RIV/68378050:_____/04:00105299!RIV/2005/AV0/A23005/N
http://linked.open.../vavai/riv/strany
  • 1943;1948
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(LN00B030), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika
  • D60
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 568230
http://linked.open...ai/riv/idVysledku
  • RIV/68378050:_____/04:00105299
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • HIV-1 protease; phenylnorstatine inhibitor; crystal packing (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • DK - Dánské království
http://linked.open...ontrolniKodProRIV
  • [1416CCF89149]
http://linked.open...i/riv/nazevZdroje
  • Acta Crystallographica Section D-Biological Crystallography
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 11
http://linked.open...iv/tvurceVysledku
  • Brynda, Jiří
  • Fábry, Milan
  • Konvalinka, Jan
  • Řezáčová, Pavlína
  • Souček, Milan
  • Sedláček, Juraj
  • Hořejší, Magdalena
  • Hradílek, Martin
  • Štouračová, Renata
http://linked.open...n/vavai/riv/zamer
issn
  • 0907-4449
number of pages
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