About: Microsatellite region in the murine oncogene src - its primary structure and variability during evolution.

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About: Microsatellite region in the murine oncogene src - its primary structure and variability during evolution. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	In the fifth intron of the Mus musculus oncogene src a complex microsatellite was discovered that consists of a CA run and 31 bp apart followed by track of TG dinucleotides interrupted by extra Gs in specific intervals. As the 31 bp interlink can assume a hairpin structure, the whole region can be viewed as an imperfect inverted repeat. The microsatellite was sequenced in imbred lines of M. m. musculus and M. m. domesticus, as well as in mice of both subspecies trapped near the hybrid zone. Differences in the length of repeat regions, insertion/deletions and simple base changes characterize the strains. Hybrids between the two species could be identified by sequencing of cloned PCR products. The structure of the microsatellite in more distant species was found to be conspicuously different. Instead of frequent (CA)18-25, we can see only (CA)8 in M. spretus, CATGCGCCCCCCA in Mus pahari and CACCCCCC in Mus caroli. No similar structure is present in the corresponding human src intron. In the fifth intron of the Mus musculus oncogene src a complex microsatellite was discovered that consists of a CA run and 31 bp apart followed by track of TG dinucleotides interrupted by extra Gs in specific intervals. As the 31 bp interlink can assume a hairpin structure, the whole region can be viewed as an imperfect inverted repeat. The microsatellite was sequenced in imbred lines of M. m. musculus and M. m. domesticus, as well as in mice of both subspecies trapped near the hybrid zone. Differences in the length of repeat regions, insertion/deletions and simple base changes characterize the strains. Hybrids between the two species could be identified by sequencing of cloned PCR products. The structure of the microsatellite in more distant species was found to be conspicuously different. Instead of frequent (CA)18-25, we can see only (CA)8 in M. spretus, CATGCGCCCCCCA in Mus pahari and CACCCCCC in Mus caroli. No similar structure is present in the corresponding human src intron. (en)
Title	Microsatellite region in the murine oncogene src - its primary structure and variability during evolution. Microsatellite region in the murine oncogene src - its primary structure and variability during evolution. (en)
skos:prefLabel	Microsatellite region in the murine oncogene src - its primary structure and variability during evolution. Microsatellite region in the murine oncogene src - its primary structure and variability during evolution. (en)
skos:notation	RIV/68378050:_____/03:23033225!RIV/2004/GA0/A23004/N
http://linked.open.../vavai/riv/strany	93
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/02/0408), Z(AV0Z5052915)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Šindelka, Radek Fučík, Vladimír Beran, Jaroslav Jonák, Jiří Ferjentsik, Zoltán
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	615419
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:23033225
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Mus musculus, c-src introns, microsatellite (en)
http://linked.open.../riv/klicoveSlovo	Mus musculus c-src introns microsatellite
http://linked.open...ontrolniKodProRIV	[8DB252357079]
http://linked.open...v/mistoKonaniAkce	Praha [CZ]
http://linked.open...i/riv/mistoVydani	Praha
http://linked.open...i/riv/nazevZdroje	Functional Genomics a Disease, Final programme and Abstract book.
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene src and Xenopus laevis development
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Fučík, Vladimír Beran, Jaroslav Jonák, Jiří Šindelka, Radek Ferjentsik, Zoltán
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2003-05-14 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	ESF IN FUNCTIONAL GENOMICS

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