About: Delivery of recombinant adeno-associated virus by jet injection.

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About: Delivery of recombinant adeno-associated virus by jet injection. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The jet injection technology was used for delivery of recombinant adeno-associated virus (rAAV).We tried to address some cell-targeting problems by using a new low-volume needleless jet-injection device teh Swiss Injector. First we tested, by electron microscopy, whether jet-injection would have any detrimental effect on rAAV particle integrity. Second, we compared transgene expression after infection of 293T cells with fired or control rAAV that expressed green fluorescent protein, beta-galactosidase, the B7.1 molecule and interleukin 2. Third an rAAV carring the genes coding for beta-gal was jet-injected into mouse subcutaneous tumours.This study demonstrated the applicability of the Swiss Injector for delivery of rAAV into tumour tissue without either vector particle integrity or the level of the transgenes expression being affected. The jet injection technology was used for delivery of recombinant adeno-associated virus (rAAV).We tried to address some cell-targeting problems by using a new low-volume needleless jet-injection device teh Swiss Injector. First we tested, by electron microscopy, whether jet-injection would have any detrimental effect on rAAV particle integrity. Second, we compared transgene expression after infection of 293T cells with fired or control rAAV that expressed green fluorescent protein, beta-galactosidase, the B7.1 molecule and interleukin 2. Third an rAAV carring the genes coding for beta-gal was jet-injected into mouse subcutaneous tumours.This study demonstrated the applicability of the Swiss Injector for delivery of rAAV into tumour tissue without either vector particle integrity or the level of the transgenes expression being affected. (en)
Title	Delivery of recombinant adeno-associated virus by jet injection. Delivery of recombinant adeno-associated virus by jet injection. (en)
skos:prefLabel	Delivery of recombinant adeno-associated virus by jet injection. Delivery of recombinant adeno-associated virus by jet injection. (en)
skos:notation	RIV/68378050:_____/03:23033133!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	687;691
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NC5900), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Štokrová, Jitka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	603013
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:23033133
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	jet injection; adeno-associated virus; gene therapy (en)
http://linked.open.../riv/klicoveSlovo	gene therapy adeno-associated virus jet injection
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[B24BDDE5D387]
http://linked.open...i/riv/nazevZdroje	International Journal of Molecular Medicine
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Gene immunotherapy of tumours with different expression of MHC-I.
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Štokrová, Jitka Šmahel, M. Jinoch, P. Janouskova, O. Nellessen, T.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1107-3756
number of pages	5 (xsd:int)

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