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rdf:type
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Description
| - a-Tocopheryl succinate (a-TOS) is a semisynthetic vitamin E analogue with high pro-apoptotic and anti-neoplastic activity [Weber, T et al. (2002) Clin. Cancer Res. 8, 863-869]. Previous studies suggested that it acts through destabilization of subcellular organelles, including mitochondria, but compelling evidence is missing. Cells treated with a-TOS showed altered mitochondrial structure, generation of free radicals, activation of the sphingomyelin cycle, relocalization of cytochrome c and Smac/Diablo, and activation of multiple caspases. A pan-caspase inhibitor suppressed caspase-3 and -6 activation and phosphatidyl serine externalization, but not decrease of mitochondrial membrane potential or generation of radicals. For a-TOS, but not Fas or TRAIL, apoptosis was suppressed by caspase-9 inhibition, while TRAIL- and Fas-resistant cells overexpressing cFLIP or CrmA were susceptible to a-TOS. The central role of mitochondria was confirmed by resistance of mtDNA-deficient cells to a-TOS, by regulation
- a-Tocopheryl succinate (a-TOS) is a semisynthetic vitamin E analogue with high pro-apoptotic and anti-neoplastic activity [Weber, T et al. (2002) Clin. Cancer Res. 8, 863-869]. Previous studies suggested that it acts through destabilization of subcellular organelles, including mitochondria, but compelling evidence is missing. Cells treated with a-TOS showed altered mitochondrial structure, generation of free radicals, activation of the sphingomyelin cycle, relocalization of cytochrome c and Smac/Diablo, and activation of multiple caspases. A pan-caspase inhibitor suppressed caspase-3 and -6 activation and phosphatidyl serine externalization, but not decrease of mitochondrial membrane potential or generation of radicals. For a-TOS, but not Fas or TRAIL, apoptosis was suppressed by caspase-9 inhibition, while TRAIL- and Fas-resistant cells overexpressing cFLIP or CrmA were susceptible to a-TOS. The central role of mitochondria was confirmed by resistance of mtDNA-deficient cells to a-TOS, by regulation (en)
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Title
| - Mitochondria Play a Central Role in Apoptosis Induced by R-Tocopheryl Succinate, an Agent with Antineoplastic Activity: Comparison with Receptor-Mediated Pro-Apoptotic Signaling.
- Mitochondria Play a Central Role in Apoptosis Induced by R-Tocopheryl Succinate, an Agent with Antineoplastic Activity: Comparison with Receptor-Mediated Pro-Apoptotic Signaling. (en)
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skos:prefLabel
| - Mitochondria Play a Central Role in Apoptosis Induced by R-Tocopheryl Succinate, an Agent with Antineoplastic Activity: Comparison with Receptor-Mediated Pro-Apoptotic Signaling.
- Mitochondria Play a Central Role in Apoptosis Induced by R-Tocopheryl Succinate, an Agent with Antineoplastic Activity: Comparison with Receptor-Mediated Pro-Apoptotic Signaling. (en)
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skos:notation
| - RIV/68378050:_____/03:23033109!RIV/2003/AV0/A23003/N
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(IAA5052905), P(LN00A026), Z(AV0Z5052915)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68378050:_____/03:23033109
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - a-TOS, TRAIL, apoptosis (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...ocetUcastnikuAkce
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http://linked.open...nichUcastnikuAkce
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Anděra, Ladislav
- Weber, T.
- Witting, P. K.
- Živný, J.
- Neužil, J.
- Weber, C.
- Higuchi, M.
- Gellert, N.
- Terman, A.
- Auge, N.
- Dalen, H.
- Lloret, A.
- Ne`gre-Salvayre, A.
- Plasilova, M.
- Sticha, M.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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