About: LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.

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About: LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src-family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. LIME thus appears to be involved in regulation of T cell activation by co-receptors. Lymphocyte membrane rafts contain molecules critical for immunoreceptor signaling. Here, we report identification of a new raft-associated adaptor protein LIME (Lck interacting molecule) expressed predominantly in T lymphocytes. LIME becomes tyrosine phosphorylated after cross-linking of the CD4 or CD8 coreceptors. Phospho-LIME associates with the Src-family kinase Lck and its negative regulator, Csk. Ectopic expression of LIME in Jurkat T cells results in an increase of Csk in lipid rafts, increased phosphorylation of Lck and higher Ca2+ response to CD3 stimulation. LIME thus appears to be involved in regulation of T cell activation by co-receptors. (en)
Title	LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (en)
skos:prefLabel	LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. (en)
skos:notation	RIV/68378050:_____/03:23033107!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	1453;1462
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LN00A026), P(LN00A079), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	10
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Brdička, Tomáš Hořejší, Václav Angelisová, Pavla Hilgert, Ivan Brdičková, Naděžda Horvath, Ondrej Pačes, Jan Špička, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	613567
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:23033107
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	immunology; T-lymphocyte; adaptor protein (en)
http://linked.open.../riv/klicoveSlovo	immunology T-lymphocyte adaptor protein
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2C5E94564567]
http://linked.open...i/riv/nazevZdroje	Journal of Experimental Medicine
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	8 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology Center of Integrated Genomics
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	198
http://linked.open...iv/tvurceVysledku	Angelisová, Pavla Brdička, Tomáš Hořejší, Václav Pačes, Jan Špička, Jiří Horváth, Ondřej Hilgert, Ivan Schraven, B. Brdičková, Naděžda Simeoni, L. Kliche, S. Merten, C.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0022-1007
number of pages	11 (xsd:int)

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