About: The roles of membrane microdomains (rafts) in T cell activation.

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About: The roles of membrane microdomains (rafts) in T cell activation. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The conference has dealt with multiple aspects of T cell immunity, the major topic was regulatory T cells. Detergent-resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essential roles in T cell receptor (TCR) signaling. These 'membrane rafts' accumulate several cytoplasmic lipid-modified molecules, including Src-family kinases, coreceptors CD4 and CD8 and transmembrane adapters LAT and PAG/Cbp, essential for either initiation or amplification of the signaling process. T cell subpopulations may differ in their use of membrane rafts. Membrane rafts are involved in many other aspects of T cell biology, such as functioning of cytokine and chemokine receptors, adhesion molecules, antigen presentation, establishing cell polarity or interaction with pathogens. Many basic raft issues, such as composition, size and heterogeneity, under native conditions, as well as the dynamics of their interactions with TCRs and other immunoreceptors, The conference has dealt with multiple aspects of T cell immunity, the major topic was regulatory T cells. Detergent-resistant membrane microdomains enriched in sphingolipids, cholesterol and glycosylphosphatidylinositol-anchored proteins play essential roles in T cell receptor (TCR) signaling. These 'membrane rafts' accumulate several cytoplasmic lipid-modified molecules, including Src-family kinases, coreceptors CD4 and CD8 and transmembrane adapters LAT and PAG/Cbp, essential for either initiation or amplification of the signaling process. T cell subpopulations may differ in their use of membrane rafts. Membrane rafts are involved in many other aspects of T cell biology, such as functioning of cytokine and chemokine receptors, adhesion molecules, antigen presentation, establishing cell polarity or interaction with pathogens. Many basic raft issues, such as composition, size and heterogeneity, under native conditions, as well as the dynamics of their interactions with TCRs and other immunoreceptors, (en)
Title	The roles of membrane microdomains (rafts) in T cell activation. The roles of membrane microdomains (rafts) in T cell activation. (en)
skos:prefLabel	The roles of membrane microdomains (rafts) in T cell activation. The roles of membrane microdomains (rafts) in T cell activation. (en)
skos:notation	RIV/68378050:_____/03:23033075!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	148;164
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LN00A026), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Hořejší, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	625959
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:23033075
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	membrane microdomain; raft; T cell (en)
http://linked.open.../riv/klicoveSlovo	membrane microdomain T cell raft
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[75E4580A1FCF]
http://linked.open...i/riv/nazevZdroje	Immunological Reviews
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	191
http://linked.open...iv/tvurceVysledku	Hořejší, Václav
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0105-2896
number of pages	16 (xsd:int)

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