About: Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function.

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About: Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous cytotrophoblast cells. HLA-G can inhibit the killing mediated by NK cells via interaction with the inhibitory NK cell receptor LIR-1. Comparison of the sequence of the HLA-G molecule to other class I MHC proteins revealed two unique cysteine residues 42 and 147. Mutating these cysteine residues resulted in a dramatic decrease in LIR-1 Ig binding. The mutated HLA-G transfectants were less effective in the inhibition of NK killing. The involvement of the cysteine residues in the formation of HLA-G protein oligomers was demonstrated. The cysteine residue 42 is critical for the expression of such complexes. These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells. The nonclassical class I MHC molecule HLA-G is selectively expressed on extravillous cytotrophoblast cells. HLA-G can inhibit the killing mediated by NK cells via interaction with the inhibitory NK cell receptor LIR-1. Comparison of the sequence of the HLA-G molecule to other class I MHC proteins revealed two unique cysteine residues 42 and 147. Mutating these cysteine residues resulted in a dramatic decrease in LIR-1 Ig binding. The mutated HLA-G transfectants were less effective in the inhibition of NK killing. The involvement of the cysteine residues in the formation of HLA-G protein oligomers was demonstrated. The cysteine residue 42 is critical for the expression of such complexes. These oligomers, unique among the class I MHC proteins, probably bind to LIR-1 with increased avidity, resulting in an enhanced inhibitory function of LIR-1 and an impaired killing function of NK cells. (en)
Title	Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. (en)
skos:prefLabel	Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. Complexes of HLA-G protein on the cell surface are important for leukocyte Ig-like receptor-1 function. (en)
skos:notation	RIV/68378050:_____/03:23033071!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	1343;1351
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(LN00A026), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Hořejší, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	601853
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:23033071
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	HLA-G; LIR-1; NK cells (en)
http://linked.open.../riv/klicoveSlovo	NK cells HLA-G LIR-1
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C15DE16BFA21]
http://linked.open...i/riv/nazevZdroje	Journal of Immunology
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	12 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Center of molecular and cellular immunology
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	171
http://linked.open...iv/tvurceVysledku	Hořejší, Václav Mandelboim, O. Hanna, J. Achdout, H. Baniyash, M. Gazit, R. Goldman-Wohl, D. Gonen-Gross, T. Levy, O. Markel, G. Mizrahi, S. Yagel, S.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0022-1767
number of pages	4 (xsd:int)

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