About: Preparation, production and labelling of scFv against TU-20 and HIV.

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About: Preparation, production and labelling of scFv against TU-20 and HIV. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Monoclonal antibody (mAb) TU 20 against beta-III neurotubulin, a specific component of neural cytoskeleton, is useful for labelling with radioactive nuclides and consequent detection of local levels of neurotubulin or its fragments in patients' tissues. Findings of increased local levels may indicate certain neurodegenerative diseases or an acute damage of neural cells. This work describes production of a recombinant single-chain form (scFv) of mAb TU20, the procedures for its labelling with iodine radionuclides, and assessment of stability and antigen-binding properties of the radiolabelled product in ELISA tests. Monoclonal antibody (mAb) TU 20 against beta-III neurotubulin, a specific component of neural cytoskeleton, is useful for labelling with radioactive nuclides and consequent detection of local levels of neurotubulin or its fragments in patients' tissues. Findings of increased local levels may indicate certain neurodegenerative diseases or an acute damage of neural cells. This work describes production of a recombinant single-chain form (scFv) of mAb TU20, the procedures for its labelling with iodine radionuclides, and assessment of stability and antigen-binding properties of the radiolabelled product in ELISA tests. (en)
Title	Preparation, production and labelling of scFv against TU-20 and HIV. Preparation, production and labelling of scFv against TU-20 and HIV. (en)
skos:prefLabel	Preparation, production and labelling of scFv against TU-20 and HIV. Preparation, production and labelling of scFv against TU-20 and HIV. (en)
skos:notation	RIV/68378050:_____/03:23033041!RIV/2004/AV0/A23004/N
http://linked.open.../vavai/riv/strany	285
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(FD-K/112), P(OE67/1), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Fábry, Milan Sedláček, Juraj Viklický, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	622739
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/03:23033041
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neurotubulin; antibody; labelling (en)
http://linked.open.../riv/klicoveSlovo	antibody labelling neurotubulin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[79BC22250B6D]
http://linked.open...i/riv/nazevZdroje	Cancer Biotherapy & Radiopharmacenticals
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	New generation of reagents for diagnostic radioimmunoassays_1 Research and development of diagnostic and therapeutic radionuclidic preparations based on monoclonal antibodies and synthetic peptides
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Fábry, Milan Kronrád, L. Sedláček, Juraj Viklický, Vladimír Málek, Z.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	1084-9785
number of pages	1 (xsd:int)

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